| pubmed-article:21134748 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:21134748 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:21134748 | lifeskim:mentions | umls-concept:C0038477 | lld:lifeskim |
| pubmed-article:21134748 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:21134748 | lifeskim:mentions | umls-concept:C0243077 | lld:lifeskim |
| pubmed-article:21134748 | lifeskim:mentions | umls-concept:C0068781 | lld:lifeskim |
| pubmed-article:21134748 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:21134748 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:21134748 | pubmed:dateCreated | 2010-12-24 | lld:pubmed |
| pubmed-article:21134748 | pubmed:abstractText | Two complementary stereospecific synthetic approaches for the preparation of unsymmetrical ortho-substituted N-(4,4-diphenylbut-3-enyl) derivatives of nipecotic acid are described. Determination of the activity of the prepared compounds at the GAT-1 transporter highlighted differing SAR requirements of the E- and Z-phenyl rings, and led to the discovery of a compound with comparable potency to tiagabine. Some attempts to replace nipecotic acid with alternative novel amino acids are also described. | lld:pubmed |
| pubmed-article:21134748 | pubmed:language | eng | lld:pubmed |
| pubmed-article:21134748 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21134748 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:21134748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21134748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21134748 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:21134748 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:21134748 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:21134748 | pubmed:issn | 1464-3405 | lld:pubmed |
| pubmed-article:21134748 | pubmed:author | pubmed-author:LeslieColin... | lld:pubmed |
| pubmed-article:21134748 | pubmed:author | pubmed-author:BernasconiGio... | lld:pubmed |
| pubmed-article:21134748 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:21134748 | pubmed:author | pubmed-author:PizziDomenica... | lld:pubmed |
| pubmed-article:21134748 | pubmed:author | pubmed-author:GrecoElisabet... | lld:pubmed |
| pubmed-article:21134748 | pubmed:author | pubmed-author:FalchiAlessan... | lld:pubmed |
| pubmed-article:21134748 | pubmed:author | pubmed-author:MangiariniLau... | lld:pubmed |
| pubmed-article:21134748 | pubmed:author | pubmed-author:NegriMicheleM | lld:pubmed |
| pubmed-article:21134748 | pubmed:author | pubmed-author:SeriCatiaC | lld:pubmed |
| pubmed-article:21134748 | pubmed:author | pubmed-author:SquagliaMiche... | lld:pubmed |
| pubmed-article:21134748 | pubmed:author | pubmed-author:CarnevaleGenn... | lld:pubmed |
| pubmed-article:21134748 | pubmed:copyrightInfo | Copyright © 2010. Published by Elsevier Ltd. | lld:pubmed |
| pubmed-article:21134748 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:21134748 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:21134748 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:21134748 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:21134748 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:21134748 | pubmed:pagination | 602-5 | lld:pubmed |
| pubmed-article:21134748 | pubmed:meshHeading | pubmed-meshheading:21134748... | lld:pubmed |
| pubmed-article:21134748 | pubmed:meshHeading | pubmed-meshheading:21134748... | lld:pubmed |
| pubmed-article:21134748 | pubmed:meshHeading | pubmed-meshheading:21134748... | lld:pubmed |
| pubmed-article:21134748 | pubmed:meshHeading | pubmed-meshheading:21134748... | lld:pubmed |
| pubmed-article:21134748 | pubmed:meshHeading | pubmed-meshheading:21134748... | lld:pubmed |
| pubmed-article:21134748 | pubmed:meshHeading | pubmed-meshheading:21134748... | lld:pubmed |
| pubmed-article:21134748 | pubmed:year | 2011 | lld:pubmed |
| pubmed-article:21134748 | pubmed:articleTitle | Stereospecific synthesis and structure-activity relationships of unsymmetrical 4,4-diphenylbut-3-enyl derivatives of nipecotic acid as GAT-1 inhibitors. | lld:pubmed |
| pubmed-article:21134748 | pubmed:affiliation | Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, Medicines Research Centre, Via A Fleming 4, 37135 Verona, Italy. domenica.a.pizzi@gsk.com | lld:pubmed |
| pubmed-article:21134748 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:21134748 | lld:chembl |
