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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2011-2-17
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pubmed:abstractText |
Although the ABCB1 (P-glycoprotein) drug transporter is a constituent of several blood-tissue barriers (i.e., blood-brain and blood-nerve), its participation in a putative blood-heart barrier has been poorly explored. ABCB1 could decrease the intracardiac concentrations of drugs that cause QT prolongation and cardiotoxicity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1078-0432
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pubmed:author |
pubmed-author:BatesSusan ESE,
pubmed-author:CabellChristopherC,
pubmed-author:ChenXiaohongX,
pubmed-author:ClarkJames AJA,
pubmed-author:FiggWilliam DWD,
pubmed-author:FrankeRyanR,
pubmed-author:GardnerErin RER,
pubmed-author:HowdenReubenR,
pubmed-author:KleebergerSteven RSR,
pubmed-author:LiewehrDavidD,
pubmed-author:Miller-DeGraffLauraL,
pubmed-author:PiekarzRichard LRL,
pubmed-author:PriceDouglas KDK,
pubmed-author:RosingDouglas RDR,
pubmed-author:SissungTristan MTM,
pubmed-author:SparreboomAlexA,
pubmed-author:SteinbergSeth MSM,
pubmed-author:VenzonDavidD,
pubmed-author:WooSukyungS
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pubmed:copyrightInfo |
©2010 AACR.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
937-46
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pubmed:meshHeading |
pubmed-meshheading:21106724-Adult,
pubmed-meshheading:21106724-Aged,
pubmed-meshheading:21106724-Aged, 80 and over,
pubmed-meshheading:21106724-Animals,
pubmed-meshheading:21106724-Arrhythmias, Cardiac,
pubmed-meshheading:21106724-Cell Line,
pubmed-meshheading:21106724-Depsipeptides,
pubmed-meshheading:21106724-Female,
pubmed-meshheading:21106724-Gene Frequency,
pubmed-meshheading:21106724-Genetic Association Studies,
pubmed-meshheading:21106724-Genotype,
pubmed-meshheading:21106724-Humans,
pubmed-meshheading:21106724-Male,
pubmed-meshheading:21106724-Mice,
pubmed-meshheading:21106724-Mice, Knockout,
pubmed-meshheading:21106724-Middle Aged,
pubmed-meshheading:21106724-Myocardium,
pubmed-meshheading:21106724-P-Glycoprotein,
pubmed-meshheading:21106724-Polymorphism, Single Nucleotide
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pubmed:year |
2011
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pubmed:articleTitle |
Impact of ABCB1 allelic variants on QTc interval prolongation.
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pubmed:affiliation |
Clinical Pharmacology Program, National Cancer Institute, Frederick, Maryland, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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