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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2010-11-25
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pubmed:abstractText |
A series of novel biphenyl pyrazole dicarboxamides were identified as potential sodium channel blockers for treatment of neuropathic pain. Compound 20 had outstanding efficacy in the Chung rat spinal nerve ligation (SNL) model of neuropathic pain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3405
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pubmed:author |
pubmed-author:AbbadieCatherineC,
pubmed-author:BrochuRichard MRM,
pubmed-author:ChakravartyPrasun KPK,
pubmed-author:DuffyJoseph LJL,
pubmed-author:EidRonsarR,
pubmed-author:FelixJohnJ,
pubmed-author:FisherMichael HMH,
pubmed-author:GarciaMariaM,
pubmed-author:JochnowitzNinaN,
pubmed-author:KaczorowskiGregory JGJ,
pubmed-author:KlattTracyT,
pubmed-author:KumarSanjeevS,
pubmed-author:LiXiaohuaX,
pubmed-author:LyonsKathryn AKA,
pubmed-author:MartinWilliam JWJ,
pubmed-author:McGowanErinE,
pubmed-author:ParsonsWilliam HWH,
pubmed-author:PriestBirgit TBT,
pubmed-author:SmithMcHardyM,
pubmed-author:TaylorBrettB,
pubmed-author:TyagarajanSriramS,
pubmed-author:WarrenVivienV,
pubmed-author:WeberAnnA,
pubmed-author:WilliamsBrandeB,
pubmed-author:WyvrattMathew JMJ,
pubmed-author:ZhouBishanB
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7479-82
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pubmed:meshHeading |
pubmed-meshheading:21106456-Animals,
pubmed-meshheading:21106456-Biphenyl Compounds,
pubmed-meshheading:21106456-Dogs,
pubmed-meshheading:21106456-Drug Evaluation, Preclinical,
pubmed-meshheading:21106456-Humans,
pubmed-meshheading:21106456-Mice,
pubmed-meshheading:21106456-Microsomes, Liver,
pubmed-meshheading:21106456-Motor Activity,
pubmed-meshheading:21106456-Neuralgia,
pubmed-meshheading:21106456-Pyrazoles,
pubmed-meshheading:21106456-Rats,
pubmed-meshheading:21106456-Sodium Channel Blockers,
pubmed-meshheading:21106456-Sodium Channels
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pubmed:year |
2010
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pubmed:articleTitle |
Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain.
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pubmed:affiliation |
Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA. sriram_tyagarajan@merck.com
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pubmed:publicationType |
Journal Article
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