Linked Life Data

21092186

Source:http://linkedlifedata.com/resource/pubmed/id/21092186

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2010-12-14
pubmed:abstractText
Single nucleotide polymorphisms (SNPs) in genes involved in the estrogen pathway appear to be associated with breast cancer risk and possibly with mammographic density (MD), but little is known of these associations among premenopausal women. This study examines the association of 11 polymorphisms in five estrogen-related genes (estrogen receptors alpha and beta (ER?, ER?), 17?-hydroxysteroid dehydrogenase 1 (HSD17B1), catechol-O-methyltransferase (COMT), cytochrome P450 1B1 (CYP1B1)) with premenopausal MD. Effect modification of four estrogen-related factors (parity, age at menarche, hormonal derivatives use and body mass index (BMI)) on this relation is also assessed.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1471-2407
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
636
pubmed:dateRevised
2011-5-30
pubmed:meshHeading
pubmed-meshheading:21092186-Adult, pubmed-meshheading:21092186-Age Factors, pubmed-meshheading:21092186-Aryl Hydrocarbon Hydroxylases, pubmed-meshheading:21092186-Body Mass Index, pubmed-meshheading:21092186-Breast Diseases, pubmed-meshheading:21092186-Breast Neoplasms, pubmed-meshheading:21092186-Catechol O-Methyltransferase, pubmed-meshheading:21092186-Chi-Square Distribution, pubmed-meshheading:21092186-Cytochrome P-450 Enzyme System, pubmed-meshheading:21092186-Estradiol Dehydrogenases, pubmed-meshheading:21092186-Estrogens, pubmed-meshheading:21092186-European Continental Ancestry Group, pubmed-meshheading:21092186-Female, pubmed-meshheading:21092186-Gene Frequency, pubmed-meshheading:21092186-Genetic Predisposition to Disease, pubmed-meshheading:21092186-Humans, pubmed-meshheading:21092186-Linear Models, pubmed-meshheading:21092186-Linkage Disequilibrium, pubmed-meshheading:21092186-Mammography, pubmed-meshheading:21092186-Middle Aged, pubmed-meshheading:21092186-Parity, pubmed-meshheading:21092186-Phenotype, pubmed-meshheading:21092186-Polymorphism, Single Nucleotide, pubmed-meshheading:21092186-Pregnancy, pubmed-meshheading:21092186-Premenopause, pubmed-meshheading:21092186-Quebec, pubmed-meshheading:21092186-Risk Assessment, pubmed-meshheading:21092186-Risk Factors
pubmed:year
2010
pubmed:articleTitle
Polymorphisms in genes involved in the estrogen pathway and mammographic density.
pubmed:affiliation
Université Laval, Département de médecine sociale et préventive, Quebec City, QC, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't