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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2011-1-10
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pubmed:abstractText |
The canonical Wnt/?-catenin pathway is an essential component of multiple developmental processes. To investigate the role of this pathway in the ectoderm during facial morphogenesis, we generated conditional ?-catenin mouse mutants using a novel ectoderm-specific Cre recombinase transgenic line. Our results demonstrate that ablating or stabilizing ?-catenin in the embryonic ectoderm causes dramatic changes in facial morphology. There are accompanying alterations in the expression of Fgf8 and Shh, key molecules that establish a signaling center critical for facial patterning, the frontonasal ectodermal zone (FEZ). These data indicate that Wnt/?-catenin signaling within the ectoderm is critical for facial development and further suggest that this pathway is an important mechanism for generating the diverse facial shapes of vertebrates during evolution.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1095-564X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Inc. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
349
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
261-9
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pubmed:dateRevised |
2011-4-28
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pubmed:meshHeading |
pubmed-meshheading:21087601-Animals,
pubmed-meshheading:21087601-DNA Primers,
pubmed-meshheading:21087601-Ectoderm,
pubmed-meshheading:21087601-Facial Bones,
pubmed-meshheading:21087601-Fibroblast Growth Factor 4,
pubmed-meshheading:21087601-Fibroblast Growth Factor 8,
pubmed-meshheading:21087601-In Situ Hybridization,
pubmed-meshheading:21087601-In Situ Nick-End Labeling,
pubmed-meshheading:21087601-Mice,
pubmed-meshheading:21087601-Mice, Transgenic,
pubmed-meshheading:21087601-Microscopy, Electron, Scanning,
pubmed-meshheading:21087601-Morphogenesis,
pubmed-meshheading:21087601-Polymerase Chain Reaction,
pubmed-meshheading:21087601-Signal Transduction,
pubmed-meshheading:21087601-Wnt Proteins,
pubmed-meshheading:21087601-beta Catenin
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pubmed:year |
2011
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pubmed:articleTitle |
Ectodermal Wnt/?-catenin signaling shapes the mouse face.
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pubmed:affiliation |
Department of Craniofacial Biology and Cell and Developmental Biology, University of Colorado Denver, 12801 East 17th Avenue, PO Box 6511, Aurora, CO 80045, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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