Source:http://linkedlifedata.com/resource/pubmed/id/21079045
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2010-12-16
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| pubmed:abstractText |
We tested hypotheses that disproportionately large placental size and vascular lesions were associated with high systolic blood pressure (SBP); and these associations might be more evident with age. The sample included 13 273 of 40 666 full-term singletons in the Collaborative Perinatal Project. Placentas were examined by pathologists blinded of pregnancy courses and outcomes. The 4-month and 7-year SBPs were measured with palpation and auscultation methods, respectively. We found that placental weight (adjusted mean difference corresponding to an increase by 1 SD 0.50 [95% CI, 0.33 to 0.68]) and placenta-fetus weight ratio (0.37 [95% CI, 0.19 to 0.54]) was positively associated with 7-year SBP but not associated with 4-month SBP. Placental largest and smallest diameters and area were negatively associated with 4-month SBP but positively with 7-year SBP. Placental thickness was negatively associated with 4-month SBP only. Placental volume was negatively associated with 4-month SBP (-0.60 [95% CI, - 0.85 to -0.35]) but positively associated with 7-year SBP (0.48 [95% CI, 0.30 to 0.67]). Thrombi in cord vessels (adjusted mean difference versus absence 2.73 [95% CI, - 0.03 to 5.50]) and decidual vessels (2.58 [95% CI, 0.24 to 4.91]), villous microinfarcts (1.63 [95% CI, 0.71 to 2.55]), necrosis at the decidual margin (1.57 [95% CI, 0.54 to 2.59]), and basalis (3.44 [95% CI, 1.55 to 5.32]) were associated with higher 4-month SBP only. We conclude that placental inefficiency, reflected by disproportionately large weight and size, predicts long-term blood pressure, whereas vascular resistance and lesions may only influence short-term blood pressure.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1524-4563
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
57
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
48-55
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| pubmed:dateRevised |
2011-4-13
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| pubmed:meshHeading |
pubmed-meshheading:21079045-Birth Weight,
pubmed-meshheading:21079045-Blood Pressure,
pubmed-meshheading:21079045-Child,
pubmed-meshheading:21079045-Cohort Studies,
pubmed-meshheading:21079045-Female,
pubmed-meshheading:21079045-Fetus,
pubmed-meshheading:21079045-Follow-Up Studies,
pubmed-meshheading:21079045-Gestational Age,
pubmed-meshheading:21079045-Humans,
pubmed-meshheading:21079045-Hypertension,
pubmed-meshheading:21079045-Infant,
pubmed-meshheading:21079045-Male,
pubmed-meshheading:21079045-Organ Size,
pubmed-meshheading:21079045-Placenta,
pubmed-meshheading:21079045-Placental Insufficiency,
pubmed-meshheading:21079045-Pregnancy,
pubmed-meshheading:21079045-Pregnancy Outcome,
pubmed-meshheading:21079045-Thrombosis
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| pubmed:year |
2011
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| pubmed:articleTitle |
Association between placental morphology and childhood systolic blood pressure.
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| pubmed:affiliation |
Epidemiology Section, Department of Community Health, Brown University, Second Floor, Providence, RI 02912, USA. xiaozhongwen@hotmail.com
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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