Linked Life Data

21071867

Source:http://linkedlifedata.com/resource/pubmed/id/21071867

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2010-11-30
pubmed:abstractText
Gold nanoparticles inhibited osteoclast (OC) formation induced by the receptor activator of nuclear factor-?B ligand (RANKL) in bone marrow-derived macrophages (BMMs). This was accompanied by a decreased level of tartrate-resistant alkaline phosphatase (TRAP) and less activation of nuclear factor (NF)-?B. The nanoparticles also reduced the production of reactive oxygen species (ROS) in response to RANKL and upregulated RANKL-induced glutathione peroxidase-1 (Gpx-1), suggesting a role as an antioxidant in the BMM. The inhibitory effects on OC formation might have been due to elevated defense against oxidative stress.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1347-6947
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2209-13
pubmed:dateRevised
2011-8-11
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Gold nanoparticles inhibited the receptor activator of nuclear factor-?b ligand (RANKL)-induced osteoclast formation by acting as an antioxidant.
pubmed:affiliation
Department of Biological Sciences (BK21 Program) and Immunomodulation Research Center, University of Ulsan, Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't