Linked Life Data

20961593

Source:http://linkedlifedata.com/resource/pubmed/id/20961593

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-11-8
pubmed:abstractText
Three decades after the eradication of smallpox, the threat of bioterrorism and outbreaks of emerging diseases such as monkeypox have renewed interest in the development of safe and effective next-generation poxvirus vaccines and biodefense research. Current smallpox vaccines contain live virus and are contraindicated for a large percentage of the population. Safer, yet still effective inactivated and subunit vaccines are needed, and epitope identification is an essential step in the development of these subunit vaccines. In this study we focused on 4 vaccinia membrane proteins known to be targeted by humoral responses in vaccinees. In spite of the narrow focus of the study we identified 36T cell epitopes, and provide additional support for the physical linkage between T and B epitopes. This information may prove useful in peptide and protein-based subunit vaccine development as well as in the study of CD4 responses to poxviruses.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1096-0341
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
20
pubmed:volume
408
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
232-40
pubmed:dateRevised
2011-10-5
pubmed:meshHeading
pubmed-meshheading:20961593-Amino Acid Sequence, pubmed-meshheading:20961593-Antibodies, Neutralizing, pubmed-meshheading:20961593-Antibodies, Viral, pubmed-meshheading:20961593-Cross Reactions, pubmed-meshheading:20961593-Epitopes, T-Lymphocyte, pubmed-meshheading:20961593-HeLa Cells, pubmed-meshheading:20961593-Histocompatibility Antigens Class II, pubmed-meshheading:20961593-Humans, pubmed-meshheading:20961593-Interferon-gamma, pubmed-meshheading:20961593-Molecular Sequence Data, pubmed-meshheading:20961593-Smallpox Vaccine, pubmed-meshheading:20961593-Species Specificity, pubmed-meshheading:20961593-T-Lymphocytes, Helper-Inducer, pubmed-meshheading:20961593-Vaccines, Subunit, pubmed-meshheading:20961593-Vaccinia virus, pubmed-meshheading:20961593-Variola virus, pubmed-meshheading:20961593-Viral Envelope Proteins
pubmed:year
2010
pubmed:articleTitle
The identification of HLA class II-restricted T cell epitopes to vaccinia virus membrane proteins.
pubmed:affiliation
Mayo Vaccine Research Group, Mayo Clinic, Rochester MN 55905, USA. Kennedy.rick@mayo.edu
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural