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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0018787,
umls-concept:C0021308,
umls-concept:C0021469,
umls-concept:C0034693,
umls-concept:C0040691,
umls-concept:C0141783,
umls-concept:C0185117,
umls-concept:C0240035,
umls-concept:C0277785,
umls-concept:C1366765,
umls-concept:C1527194,
umls-concept:C1879547,
umls-concept:C2911684
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pubmed:issue |
3
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pubmed:dateCreated |
2011-1-13
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pubmed:abstractText |
Interstitial fibrosis plays a causal role in the development of heart failure after chronic myocardial infarction (MI), and anti-fibrotic therapy represents a promising strategy to mitigate this pathological process. The purpose of this study was to investigate the effect of long-term administration of scutellarin (Scu) on cardiac interstitial fibrosis of myocardial infarct rats and the underlying mechanisms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apigenin,
http://linkedlifedata.com/resource/pubmed/chemical/Collagen,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Drugs, Chinese Herbal,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/MAPK1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/scutellarin
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1476-5381
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pubmed:author |
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pubmed:copyrightInfo |
© 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.
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pubmed:issnType |
Electronic
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
688-700
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pubmed:meshHeading |
pubmed-meshheading:20942814-Animals,
pubmed-meshheading:20942814-Apigenin,
pubmed-meshheading:20942814-Collagen,
pubmed-meshheading:20942814-Cytokines,
pubmed-meshheading:20942814-Drugs, Chinese Herbal,
pubmed-meshheading:20942814-Echocardiography,
pubmed-meshheading:20942814-Erigeron,
pubmed-meshheading:20942814-Fibrosis,
pubmed-meshheading:20942814-Glucuronic Acids,
pubmed-meshheading:20942814-Heart Failure,
pubmed-meshheading:20942814-Hemodynamics,
pubmed-meshheading:20942814-Male,
pubmed-meshheading:20942814-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:20942814-Myocardial Infarction,
pubmed-meshheading:20942814-Phytotherapy,
pubmed-meshheading:20942814-Rats,
pubmed-meshheading:20942814-Rats, Wistar,
pubmed-meshheading:20942814-Transforming Growth Factor beta1,
pubmed-meshheading:20942814-Ventricular Dysfunction, Left,
pubmed-meshheading:20942814-Ventricular Remodeling,
pubmed-meshheading:20942814-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2011
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pubmed:articleTitle |
Scutellarin alleviates interstitial fibrosis and cardiac dysfunction of infarct rats by inhibiting TGF?1 expression and activation of p38-MAPK and ERK1/2.
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pubmed:affiliation |
Department of Pharmacology, Harbin Medical University, Harbin, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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