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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-12-20
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pubmed:abstractText |
The human homolog of the mouse double minute 2 (MDM2) oncogene is amplified in about 20% of sarcomas. The measurement of the MDM2 amplification can aid in classification and may provide a predictive value for recently formulated therapies targeting MDM2. We have developed and validated an automated bright field dual-color in situ hybridization application to detect MDM2 gene amplification.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1533-4058
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pubmed:author |
pubmed-author:McElhinnyAbigailA,
pubmed-author:MillerMelanieM,
pubmed-author:NagleRaymond BRB,
pubmed-author:NielsenAlmaA,
pubmed-author:Pestic-DragovichLidijaL,
pubmed-author:RochePatP,
pubmed-author:RubinBrian PBP,
pubmed-author:RuegerRuedigerR,
pubmed-author:SinghShaliniS,
pubmed-author:TubbsRaymond RRR,
pubmed-author:WangMariaM,
pubmed-author:WangZhenZ,
pubmed-author:WuPingP,
pubmed-author:ZhangWenjunW
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pubmed:issnType |
Electronic
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
54-61
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pubmed:meshHeading |
pubmed-meshheading:20881839-Aneuploidy,
pubmed-meshheading:20881839-Animals,
pubmed-meshheading:20881839-Chromosomes, Human, Pair 12,
pubmed-meshheading:20881839-Gene Amplification,
pubmed-meshheading:20881839-Humans,
pubmed-meshheading:20881839-In Situ Hybridization,
pubmed-meshheading:20881839-In Situ Hybridization, Fluorescence,
pubmed-meshheading:20881839-Mice,
pubmed-meshheading:20881839-Oligonucleotide Probes,
pubmed-meshheading:20881839-Proto-Oncogene Proteins c-mdm2,
pubmed-meshheading:20881839-Sarcoma
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pubmed:year |
2011
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pubmed:articleTitle |
Automated brightfield dual-color in situ hybridization for detection of mouse double minute 2 gene amplification in sarcomas.
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pubmed:affiliation |
Ventana Medical Systems, Inc., Tucson, AZ 85755, USA.
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pubmed:publicationType |
Journal Article
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