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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-9-29
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pubmed:abstractText |
Several lines of evidence point to an important role for BP1, an isoform of DLX4 homeobox gene, in breast carcinogenesis and progression. BRCA1 is a well-known player in the etiology of breast cancer. While familial breast cancer is often marked by BRCA1 mutation and subsequent loss of heterozygosity, sporadic breast cancers exhibit reduced expression of wild type BRCA1, and loss of BRCA1 expression may result in tumor development and progression.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1449-2288
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pubmed:author |
pubmed-author:BergPatricia EPE,
pubmed-author:DengChuxiaC,
pubmed-author:FormoloTrina ATA,
pubmed-author:FuSidney WSW,
pubmed-author:FuYeboY,
pubmed-author:HindleAnne KAK,
pubmed-author:KlukBrian JBJ,
pubmed-author:ManYan-gaoYG,
pubmed-author:McCaffreyTimothy ATA,
pubmed-author:SiegelRobert SRS,
pubmed-author:ZhangLeiL
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pubmed:issnType |
Electronic
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
513-24
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pubmed:meshHeading |
pubmed-meshheading:20877436-Binding Sites,
pubmed-meshheading:20877436-Breast Neoplasms,
pubmed-meshheading:20877436-Cell Line, Tumor,
pubmed-meshheading:20877436-Chromatin Immunoprecipitation,
pubmed-meshheading:20877436-Consensus Sequence,
pubmed-meshheading:20877436-Electrophoretic Mobility Shift Assay,
pubmed-meshheading:20877436-Female,
pubmed-meshheading:20877436-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20877436-Genes, BRCA1,
pubmed-meshheading:20877436-Homeodomain Proteins,
pubmed-meshheading:20877436-Humans,
pubmed-meshheading:20877436-Protein Isoforms,
pubmed-meshheading:20877436-RNA Interference,
pubmed-meshheading:20877436-Repressor Proteins,
pubmed-meshheading:20877436-Sequence Analysis, DNA,
pubmed-meshheading:20877436-Transcription Factors
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pubmed:year |
2010
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pubmed:articleTitle |
BP1, an isoform of DLX4 homeoprotein, negatively regulates BRCA1 in sporadic breast cancer.
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pubmed:affiliation |
Department of Medicine, Division of Genomic Medicine, George Washington University Medical Center, Washington, DC, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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