Linked Life Data

20859975

Source:http://linkedlifedata.com/resource/pubmed/id/20859975

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
44
pubmed:dateCreated
2010-10-21
pubmed:abstractText
Synthetic organic reactions are a fundamental enabler of small-molecule drug discovery, and the vast majority of medicinal chemists are initially trained--either at universities or within industry--as synthetic organic chemists. The sheer breadth of synthetic methodology available to the medicinal chemist represents an almost endless source of innovation. But what reactions do medicinal chemists use in drug discovery? And what criteria do they use in selecting synthetic methodology? Why are arrays (small focused libraries) so powerful in the lead-optimization process? In this Minireview, we suggest some answers to these questions and also describe how we have tried to expand the number of robust reactions available to the medicinal chemist.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1521-3773
pubmed:author
pubmed:issnType
Electronic
pubmed:day
25
pubmed:volume
49
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8082-91
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Factors determining the selection of organic reactions by medicinal chemists and the use of these reactions in arrays (small focused libraries).
pubmed:affiliation
Respiratory CEDD, GlaxoSmithKline, Gunnels Wood Road, Stevenage, SG1 2NY, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't