Linked Life Data

2085465

Source:http://linkedlifedata.com/resource/pubmed/id/2085465

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1991-5-22
pubmed:abstractText
The immunoglobulin supergene family members have been shown to be involved in cell-cell recognition and interaction during cell growth and differentiation. Neural cell adhesion molecule, myelin-associated glycoprotein, and carcinoembryonic antigen (CEA) are immunoglobulin supergene family members which can mediate cell adhesion. We show here that nonspecific cross-reacting antigen (NCA), a closely related CEA family member, is found on the surface of rodent cells transfected with functional NCA complementary DNA in different glycosylated forms, all of which can be deglycosylated to an Mr 35,000 core protein. Furthermore, NCA can mediate Ca2(+)-independent, homotypic aggregation of these NCA-producing transfectant cells. Since CEA has three internal repeated C2-set, immunoglobulin-like domains, whereas NCA has one, only one such domain is required for the intercellular adhesive function. We also demonstrate that NCA- and CEA-producing transfectants can form heterotypic aggregates, whereas mixtures of CEA or NCA transfectants and neural cell adhesion molecule or long form-myelin-associated glycoprotein transfectants sort themselves out into homotypic aggregates. The results suggest that subsets of the immunoglobulin superfamily, such as the CEA family, can be used in both homotypic and heterotypic cellular interactions, whereas less closely related members of the family can be used to separate different cell types by strictly homotypic interactions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1044-9523
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-15
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:2085465-Animals, pubmed-meshheading:2085465-Antigens, Neoplasm, pubmed-meshheading:2085465-Carcinoembryonic Antigen, pubmed-meshheading:2085465-Cell Adhesion, pubmed-meshheading:2085465-Cell Adhesion Molecules, pubmed-meshheading:2085465-Cell Adhesion Molecules, Neuronal, pubmed-meshheading:2085465-Cell Aggregation, pubmed-meshheading:2085465-Cell Line, pubmed-meshheading:2085465-Cricetinae, pubmed-meshheading:2085465-Cricetulus, pubmed-meshheading:2085465-DNA, pubmed-meshheading:2085465-DNA, Antisense, pubmed-meshheading:2085465-Genes, Immunoglobulin, pubmed-meshheading:2085465-Glycoproteins, pubmed-meshheading:2085465-Glycosylation, pubmed-meshheading:2085465-Membrane Glycoproteins, pubmed-meshheading:2085465-Multigene Family, pubmed-meshheading:2085465-Organ Specificity, pubmed-meshheading:2085465-Protein Processing, Post-Translational, pubmed-meshheading:2085465-Recombinant Fusion Proteins, pubmed-meshheading:2085465-Transfection
pubmed:year
1990
pubmed:articleTitle
Specificity of intercellular adhesion mediated by various members of the immunoglobulin supergene family.
pubmed:affiliation
Biochemistry Department, McGill University, Montreal, Quebec, Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't