Linked Life Data

2085286

Source:http://linkedlifedata.com/resource/pubmed/id/2085286

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-5-16
pubmed:abstractText
The present studies examined serotonergic contractile sensitivity mediated by 5-HT2 receptors in thoracic and abdominal regions of rat aorta. Increasing concentrations of 5-HT (10 nM-100 microM) in the presence or absence of the selective 5-HT2 antagonist ketanserin (5 nM) produced differential concentration-response curves in thoracic and abdominal aortic ring preparations. Abdominal aortic preparations were significantly more sensitive to 5-HT than thoracic regions. Regional variations in maximal response produced by 5-HT were not observed. Ketanserin produced distinct rightward shifts in the 5-HT concentration-response curves, revealing a similar profile of sensitivity in thoracic and abdominal aorta. These data suggest that regional patterns in 5-HT-induced contractile responses in rat aorta are mediated by 5-HT2 sites exhibiting differential, site specific sensitivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0098-6127
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
47-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Regional differences in serotonergic contractile sensitivity mediated by 5-HT2 receptors in rat aorta.
pubmed:affiliation
Neuropharmacology Laboratory College of Pharmacy and Health Sciences, Drake University, Des Moines, IA 50311.
pubmed:publicationType
Journal Article, Comparative Study, In Vitro, Research Support, Non-U.S. Gov't