Source:http://linkedlifedata.com/resource/pubmed/id/20823314
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
18
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pubmed:dateCreated |
2010-9-8
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pubmed:abstractText |
Gene regulation commonly involves interaction among DNA, proteins and biochemical conditions. Using chromatin immunoprecipitation (ChIP) technologies, protein-DNA interactions are routinely detected in the genome scale. Computational methods that detect weak protein-binding signals and simultaneously maintain a high specificity yet remain to be challenging. An attractive approach is to incorporate biologically relevant data, such as protein co-occupancy, to improve the power of protein-binding detection. We call the additional data related with the target protein binding as supporting tracks.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1367-4811
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
i504-10
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pubmed:meshHeading |
pubmed-meshheading:20823314-Algorithms,
pubmed-meshheading:20823314-Animals,
pubmed-meshheading:20823314-Binding Sites,
pubmed-meshheading:20823314-Cell Line,
pubmed-meshheading:20823314-Chromatin Immunoprecipitation,
pubmed-meshheading:20823314-Computer Simulation,
pubmed-meshheading:20823314-DNA,
pubmed-meshheading:20823314-GATA1 Transcription Factor,
pubmed-meshheading:20823314-Mathematical Computing,
pubmed-meshheading:20823314-Mice,
pubmed-meshheading:20823314-Protein Binding
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pubmed:year |
2010
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pubmed:articleTitle |
A varying threshold method for ChIP peak-calling using multiple sources of information.
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pubmed:affiliation |
Department of Computer Science and Engineering, The Pennsylvania State University, University Park, PA 16802, USA.
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pubmed:publicationType |
Journal Article,
Evaluation Studies,
Research Support, N.I.H., Extramural
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