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pubmed:abstractText |
While there is considerable evidence that the ovarian hormone estradiol reduces food intake in female rats, it is unclear which estrogen receptor (ER) subtype, ER? or ER?, mediates this effect. While several studies have demonstrated that activation of ER?, but not ER?, is sufficient to reduce food intake in ovariectomized (OVX) rats, there are limited data regarding which receptor subtype is necessary. Here we used the selective ER? and ERß antagonists, MPrP and PHTPP, respectively, to investigate this question. We found that antagonism of ER?, but not ER?, prevented the decrease in food intake following acute administration of estradiol in OVX rats. In addition, antagonism of ER? prevented the estrous-related, phasic reduction in food intake that occurs in response to the rise in circulating levels of estradiol in cycling rats. We conclude that activation of ER? is necessary for the anorexigenic effects of exogenous and endogenous estradiol in female rats.
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