|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2010-8-31
|
|
pubmed:abstractText |
The loss of AP-2alpha and increased activity of cAMP-responsive element binding (CREB) protein are two hallmarks of malignant progression of cutaneous melanoma. However, the molecular mechanism responsible for the loss of AP-2alpha during melanoma progression remains unknown.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1932-6203
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
5
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
e12452
|
|
pubmed:meshHeading |
pubmed-meshheading:20805990-Animals,
pubmed-meshheading:20805990-Antigens, CD146,
pubmed-meshheading:20805990-Cell Line, Tumor,
pubmed-meshheading:20805990-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:20805990-Cyclin-Dependent Kinase Inhibitor p21,
pubmed-meshheading:20805990-Disease Progression,
pubmed-meshheading:20805990-E2F1 Transcription Factor,
pubmed-meshheading:20805990-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20805990-Humans,
pubmed-meshheading:20805990-Melanoma,
pubmed-meshheading:20805990-Neoplasm Metastasis,
pubmed-meshheading:20805990-Phosphorylation,
pubmed-meshheading:20805990-Promoter Regions, Genetic,
pubmed-meshheading:20805990-Transcription, Genetic,
pubmed-meshheading:20805990-Transcription Factor AP-2,
pubmed-meshheading:20805990-Up-Regulation
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
CREB inhibits AP-2alpha expression to regulate the malignant phenotype of melanoma.
|
|
pubmed:affiliation |
Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, United States of America.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
