Linked Life Data

20707590

Source:http://linkedlifedata.com/resource/pubmed/id/20707590

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-8-16
pubmed:abstractText
We study the mechanical unfolding pathways of the FnIII(10) domain of fibronectin by means of an Ising-like model, using both constant force and constant velocity protocols. At high forces and high velocities our results are consistent with experiments and previous computational studies. Moreover, the simplicity of the model allows us to probe the biologically relevant low force regime, where we predict the existence of two intermediates with very close elongations. The unfolding pathway is characterized by stochastic transitions between these two intermediates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1089-7690
pubmed:author
pubmed:issnType
Electronic
pubmed:day
14
pubmed:volume
133
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
065101
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Pathways of mechanical unfolding of FnIII(10): low force intermediates.
pubmed:affiliation
Dipartimento di Fisica and CNISM, Politecnico di Torino, c. Duca degli Abruzzi 24, 10129 Torino, Italy. michele.caraglio@polito.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't