Linked Life Data

20702796

Source:http://linkedlifedata.com/resource/pubmed/id/20702796

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:20702796rdf:typepubmed:Citationlld:pubmed
pubmed-article:20702796lifeskim:mentionsumls-concept:C0030567lld:lifeskim
pubmed-article:20702796lifeskim:mentionsumls-concept:C0599779lld:lifeskim
pubmed-article:20702796lifeskim:mentionsumls-concept:C0012155lld:lifeskim
pubmed-article:20702796lifeskim:mentionsumls-concept:C0027746lld:lifeskim
pubmed-article:20702796lifeskim:mentionsumls-concept:C0436331lld:lifeskim
pubmed-article:20702796pubmed:issue4lld:pubmed
pubmed-article:20702796pubmed:dateCreated2010-10-1lld:pubmed
pubmed-article:20702796pubmed:abstractTextDespite numerous clinical studies supporting a link between type 2 diabetes (T2D) and Parkinson's disease (PD), the clinical literature remains equivocal. We, therefore, sought to address the relationship between insulin resistance and nigrostriatal dopamine (DA) in a preclinical animal model. High-fat feeding in rodents is an established model of insulin resistance, characterized by increased adiposity, systemic oxidative stress, and hyperglycemia. We subjected rats to a normal chow or high-fat diet for 5 wk before infusing 6-hydroxydopamine (6-OHDA) into the medial forebrain bundle. Our goal was to determine whether a high-fat diet and the resulting peripheral insulin resistance would exacerbate 6-OHDA-induced nigrostriatal DA depletion. Prior to 6-OHDA infusion, animals on the high-fat diet exhibited greater body weight, increased adiposity, and impaired glucose tolerance. Two weeks after 6-OHDA, locomotor activity was tested, and brain and muscle tissue was harvested. Locomotor activity did not differ between the groups nor did cholesterol levels or measures of muscle atrophy. High-fat-fed animals exhibited higher homeostatic model assessment of insulin resistance (HOMA-IR) values and attenuated insulin-stimulated glucose uptake in fast-twitch muscle, indicating decreased insulin sensitivity. Animals in the high-fat group also exhibited greater DA depletion in the substantia nigra and the striatum, which correlated with HOMA-IR and adiposity. Decreased phosphorylation of HSP27 and degradation of I?B? in the substantia nigra indicate increased tissue oxidative stress. These findings support the hypothesis that a diet high in fat and the resulting insulin resistance may lower the threshold for developing PD, at least following DA-specific toxin exposure.lld:pubmed
pubmed-article:20702796pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20702796pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20702796pubmed:granthttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20702796pubmed:languageenglld:pubmed
pubmed-article:20702796pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20702796pubmed:citationSubsetIMlld:pubmed
pubmed-article:20702796pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20702796pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20702796pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20702796pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20702796pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20702796pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20702796pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20702796pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20702796pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:20702796pubmed:statusMEDLINElld:pubmed
pubmed-article:20702796pubmed:monthOctlld:pubmed
pubmed-article:20702796pubmed:issn1522-1490lld:pubmed
pubmed-article:20702796pubmed:authorpubmed-author:StanfordJohn...lld:pubmed
pubmed-article:20702796pubmed:authorpubmed-author:GeigerPaige...lld:pubmed
pubmed-article:20702796pubmed:authorpubmed-author:BomhoffGregor...lld:pubmed
pubmed-article:20702796pubmed:authorpubmed-author:MorrisJill...lld:pubmed
pubmed-article:20702796pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20702796pubmed:volume299lld:pubmed
pubmed-article:20702796pubmed:ownerNLMlld:pubmed
pubmed-article:20702796pubmed:authorsCompleteYlld:pubmed
pubmed-article:20702796pubmed:paginationR1082-90lld:pubmed
pubmed-article:20702796pubmed:dateRevised2011-11-17lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:meshHeadingpubmed-meshheading:20702796...lld:pubmed
pubmed-article:20702796pubmed:year2010lld:pubmed
pubmed-article:20702796pubmed:articleTitleNeurodegeneration in an animal model of Parkinson's disease is exacerbated by a high-fat diet.lld:pubmed
pubmed-article:20702796pubmed:affiliationDepartment of Molecular and Integrative Physiology, Univ. of Kansas Medical Center, Kansas City, 66160, USA.lld:pubmed
pubmed-article:20702796pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20702796pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:20702796pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:20702796lld:pubmed