Linked Life Data

20696273

Source:http://linkedlifedata.com/resource/pubmed/id/20696273

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-9-9
pubmed:abstractText
Cadmium (Cd) is a non-essential toxic heavy metal with the potential to induce oxidative stress. Cd toxicity and its capacity for accumulation in aquatic habitats have earned its recognition as a pollutant of immediate and widespread concern. To obtain a better understanding of oxidative stress-associated gene expression in different tissues, six antioxidant genes such as catalase (CAT), glutathione reductase (GR), glutathione peroxidase 1a (GPx1a), glutathione peroxidase 1b (GPx1b), Cu/Zn superoxide dismutase (Cu/Zn-SOD), and Mn superoxide dismutase (Mn-SOD) were cloned and fully sequenced in the river pufferfish, Takifugu obscurus. On tissue specific mRNA expression, the liver showed the highest expression when compared to other tissues, even though each antioxidant gene showed different modes of expression patterns in the examined tissues. Of the various antioxidant genes, GR was the most highly expressed in the liver, followed by CAT, GPx1, and Cu/Zn-SOD. For the time-course experiment, all the antioxidant genes were significantly induced over time except for Cu/Zn-SOD in the liver, and there was a 5-fold induction in hepatic GR, CAT, and Mn-SOD mRNA compared to the control. These findings indicate that the liver of T. obscurus has a robust antioxidant system. In addition, these results suggest that Cd exposure modulates the expression of antioxidant genes, and would indicate that the antioxidant genes would be a relevant biomarker of trace metal pollution such as Cd exposure in T. obscurus.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1532-0456
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Print
pubmed:volume
152
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
473-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Effect of cadmium exposure on expression of antioxidant gene transcripts in the river pufferfish, Takifugu obscurus (Tetraodontiformes).
pubmed:affiliation
National Research Lab of Marine Molecular and Environmental Bioscience, Department of Chemistry, College of Natural Sciences, Hanyang University, Seoul 133-791, South Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't