Linked Life Data

20693981

Source:http://linkedlifedata.com/resource/pubmed/id/20693981

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2010-10-4
pubmed:abstractText
Based on the molecular profiling of astrocytomas, we previously identified a series of genes involved in astrocytoma invasion. Of these, tissue inhibitor of metalloproteinase-4 (TIMP-4) was found to be overexpressed in pilocytic astrocytomas relative to diffuse astrocytomas of any histological grade. Although some data suggest that TIMP-4 may be an anti-tumoral actor in astrocytomas, recent findings challenge this concept. The present study aims to investigate the diagnostic and prognostic values of TIMP-4 and its putative partner CD63 in human astrocytomas. Tissue microarray and image analysis were first carried out to quantitatively analyze the immunohistochemical expression of these proteins in 471 gliomas including 354 astrocytomas. Pathological semi-quantitative scores of both markers' expression were then established and correlated to astrocytoma diagnosis and patient prognosis. TIMP-4 and CD63 expressions were both overexpressed in astrocytomas compared with oligodendrogliomas (P<0.001) and in pilocytic astrocytomas compared with grade II diffuse astrocytomas (P<0.001). In glioblastomas, high TIMP-4/CD63 co-expression scores were identified as independent prognostic factors associated with progression and shorter survival. In conclusion, this work provides the first evidence of a TIMP-4/CD63 association in astrocytoma tumor cells. It identifies TIMP-4 and CD63 as markers of the astrocytic phenotype in patients with gliomas. In addition, this work highlights the contribution of high TIMP-4/CD63 co-expression to the adverse outcomes of patients with glioblastomas.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1530-0285
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1418-28
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:20693981-Antigens, CD, pubmed-meshheading:20693981-Antigens, CD63, pubmed-meshheading:20693981-Astrocytoma, pubmed-meshheading:20693981-Brain Neoplasms, pubmed-meshheading:20693981-Female, pubmed-meshheading:20693981-Humans, pubmed-meshheading:20693981-Image Processing, Computer-Assisted, pubmed-meshheading:20693981-Immunohistochemistry, pubmed-meshheading:20693981-Immunoprecipitation, pubmed-meshheading:20693981-Kaplan-Meier Estimate, pubmed-meshheading:20693981-Male, pubmed-meshheading:20693981-Middle Aged, pubmed-meshheading:20693981-Platelet Membrane Glycoproteins, pubmed-meshheading:20693981-Prognosis, pubmed-meshheading:20693981-Tissue Array Analysis, pubmed-meshheading:20693981-Tissue Inhibitor of Metalloproteinases, pubmed-meshheading:20693981-Tumor Markers, Biological
pubmed:year
2010
pubmed:articleTitle
TIMP-4 and CD63: new prognostic biomarkers in human astrocytomas.
pubmed:affiliation
Department of Pathology, Erasme University Hospital, Brussels, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't