Linked Life Data

20692345

Source:http://linkedlifedata.com/resource/pubmed/id/20692345

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-10-22
pubmed:abstractText
The Ca(2+)-stimulated adenylate cyclase 1 (AC1) is a key mediator of retinotopic map refinement and is required for the retraction response of retinal growth cones to the guidance cue ephrin-A5. We show here that AC1 is dynamically expressed in subpopulations of motor neurons in the spinal cord and sensory neurons of the dorsal root ganglia during development. AC1 was first detected around E12.5 in motoneurons of the medial aspect of the lateral motor column (LMCm) and the lateral region of the medial motor column (MMCl), which project to the ventral limb and body wall musculature, respectively. Expression levels gradually increased until they reached a maximum at a time when peripheral sensory and motor axons branch and establish connections with their targets. In barrelless mice, where a mutation inactivates the AC1 gene, sensory projections to the skin in the limbs and trunk region as well as innervations of the intercostal musculature provided by MMCl axons show increased branching. These results suggest a function of AC1 in the formation of peripheral nerve trajectories such as branching and pruning, after the initial projections have been laid down.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1095-9327
pubmed:author
pubmed:copyrightInfo
Copyright © 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
439-48
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Adenylate Cyclase 1 modulates peripheral nerve branching patterns.
pubmed:affiliation
Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Ingolstädter Landstrasse 1, D-85764 Munich/Neuherberg, Germany.
pubmed:publicationType
Journal Article