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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2010-10-25
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pubmed:abstractText |
Endothelial lipase (EL) is a new member of triacylglycerol lipase family that has been shown to decrease high-density lipoprotein (HDL) cholesterol levels leading to increased risk of atherosclerosis. Its expression is increased during inflammation and by inflammatory cytokines. Sulforaphane (SFN) is a naturally occurring isothiocyanate present in cruciferous vegetables that has antioxidant and anti-inflammatory effects. Nuclear factor (NF)-?B is one of the molecular targets for SFN-mediated protective effects. Our aim was therefore to assess whether SFN could impact on EL expression via modulation of NF-?B pathway.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1879-1484
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pubmed:author |
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pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:volume |
213
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
122-8
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pubmed:meshHeading |
pubmed-meshheading:20688330-Antioxidants,
pubmed-meshheading:20688330-Atherosclerosis,
pubmed-meshheading:20688330-Cells, Cultured,
pubmed-meshheading:20688330-Endothelial Cells,
pubmed-meshheading:20688330-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:20688330-Humans,
pubmed-meshheading:20688330-I-kappa B Kinase,
pubmed-meshheading:20688330-Isothiocyanates,
pubmed-meshheading:20688330-Lipase,
pubmed-meshheading:20688330-Models, Biological,
pubmed-meshheading:20688330-NF-kappa B,
pubmed-meshheading:20688330-Protein Binding,
pubmed-meshheading:20688330-Thiocyanates,
pubmed-meshheading:20688330-Umbilical Veins,
pubmed-meshheading:20688330-Vegetables
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pubmed:year |
2010
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pubmed:articleTitle |
Sulforaphane inhibits endothelial lipase expression through NF-?B in endothelial cells.
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pubmed:affiliation |
The Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, P.O. Box 1627, Neulaniementie 2, FIN-70211 Kuopio, Finland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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