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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-11-5
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pubmed:abstractText |
Natriuretic peptides (NPs) inhibit cardiomyocyte hypertrophy through a cyclic GMP (cGMP)-dependent process, although these effects are associated with substantial vasodilatation. In this study, we used CU-NP, a non-vasodilatating novel NP synthesized from the ring structure of human C-type NP (CNP) and both C- and N-termini of urodilatin, and investigated whether it can directly modulate cardiomyocyte hypertrophy.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
434-42
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pubmed:meshHeading |
pubmed-meshheading:20679416-Animals,
pubmed-meshheading:20679416-Atrial Natriuretic Factor,
pubmed-meshheading:20679416-Calcineurin,
pubmed-meshheading:20679416-Cell Nucleus,
pubmed-meshheading:20679416-Cells, Cultured,
pubmed-meshheading:20679416-Cyclic GMP,
pubmed-meshheading:20679416-Dose-Response Relationship, Drug,
pubmed-meshheading:20679416-Hypertrophy,
pubmed-meshheading:20679416-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:20679416-Models, Animal,
pubmed-meshheading:20679416-Myocytes, Cardiac,
pubmed-meshheading:20679416-Peptide Fragments,
pubmed-meshheading:20679416-Rats,
pubmed-meshheading:20679416-Rats, Sprague-Dawley,
pubmed-meshheading:20679416-Recombinant Fusion Proteins,
pubmed-meshheading:20679416-Signal Transduction,
pubmed-meshheading:20679416-Sodium,
pubmed-meshheading:20679416-Sodium-Hydrogen Antiporter
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pubmed:year |
2010
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pubmed:articleTitle |
A novel chimeric natriuretic peptide reduces cardiomyocyte hypertrophy through the NHE-1-calcineurin pathway.
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pubmed:affiliation |
Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, University of Western Ontario, Medical Sciences Building, London, ON, Canada N6A 5C1.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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