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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-8-3
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pubmed:abstractText |
Although prior research has examined the genetic correlates of antisocial behavior, molecular genetics influences on psychopathic traits remain largely unknown. Consequently, we investigated the influence of polymorphic variation at the serotonin transporter protein gene (SLC6A4) and socioeconomic resources (SES) on psychopathic traits in youth across two distinct samples in two separate studies. In Study 1, a main effect of serotonin transporter (5-HTTLPR) genotype was associated with the impulsivity dimension of psychopathy. That is, individuals homozygous for the short allele evidenced more impulsivity than did those homozygous for the long allele. In contrast, a gene-environment interaction was associated with the callous-unemotional and narcissistic features of psychopathy. Callous-unemotional and narcissistic traits increased as SES decreased only among youths with the homozygous-long (l/l) genotype, a novel finding replicated and extended in Study 2. These studies provide preliminary results that the l/l genotype confers risk for the emotional deficits and predatory interpersonal traits associated with psychopathy among youths raised in disadvantaged environments.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/DA18647,
http://linkedlifedata.com/resource/pubmed/grant/F31 MH086178,
http://linkedlifedata.com/resource/pubmed/grant/R01 DA018647-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 DA018647-01A1S1,
http://linkedlifedata.com/resource/pubmed/grant/R01 DA018647-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 DA018647-02S1,
http://linkedlifedata.com/resource/pubmed/grant/R01 DA018647-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 DA018647-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 DA018647-04S1,
http://linkedlifedata.com/resource/pubmed/grant/R01 DA018647-05,
http://linkedlifedata.com/resource/pubmed/grant/R01 DA018647-05S1
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-10050973,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-11113963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-11147105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-11515752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-12161658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-12870570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-14696028,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-15625622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-15699291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-15953488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-16093315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-16412987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-16690085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-16741214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-16761546,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-17050915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-1794096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-19000200,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-19531786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-8436703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20677849-9402979
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1939-1846
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2010 APA, all rights reserved
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pubmed:issnType |
Electronic
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
604-9
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pubmed:dateRevised |
2011-8-3
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pubmed:meshHeading |
pubmed-meshheading:20677849-Adolescent,
pubmed-meshheading:20677849-Alleles,
pubmed-meshheading:20677849-Antisocial Personality Disorder,
pubmed-meshheading:20677849-Child,
pubmed-meshheading:20677849-Female,
pubmed-meshheading:20677849-Genotype,
pubmed-meshheading:20677849-Homozygote,
pubmed-meshheading:20677849-Humans,
pubmed-meshheading:20677849-Impulsive Behavior,
pubmed-meshheading:20677849-Male,
pubmed-meshheading:20677849-Polymorphism, Genetic,
pubmed-meshheading:20677849-Psychiatric Status Rating Scales,
pubmed-meshheading:20677849-Regression Analysis,
pubmed-meshheading:20677849-Risk Factors,
pubmed-meshheading:20677849-Serotonin Plasma Membrane Transport Proteins,
pubmed-meshheading:20677849-Socioeconomic Factors
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pubmed:year |
2010
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pubmed:articleTitle |
Serotonin transporter gene associations with psychopathic traits in youth vary as a function of socioeconomic resources.
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pubmed:affiliation |
Department of Psychology, University of Illinois at Urbana-Champaign, 603 East Daniel Street, Champaign, IL 61820, USA. nsamimi2@illinois.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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