Linked Life Data

20677166

Source:http://linkedlifedata.com/resource/pubmed/id/20677166

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-9-30
pubmed:abstractText
Pancreatic carcinoma is one of the most malignant and aggressive cancers. The identification of prognostic factors is thought to be useful in directing treatment. Transcription factor Jun dimerization protein 2 (JDP2), a member of the activator protein 1 (AP-1) family, acts as an AP-1 inhibitor and has been implicated in many cellular processes including carcinogenesis. The role of JDP2 in the development of pancreatic carcinoma, however, remained elusive. In this study we examined the expression levels of JDP2 in 36 pancreatic carcinoma samples by Western blotting and found that JDP2 expression was significantly downregulated in pancreatic carcinoma samples compared with peritumoral tissues. The decrease in JDP2 expression was correlated with lymph node metastasis and distant metastasis and strongly associated with the post-surgery survival time. These results indicate a possible connection between JDP2 expression and metastasis in pancreatic carcinoma and suggest that JDP2 can serve as a biomarker to predict the prognosis of patients with this cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1724-6008
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
136-40
pubmed:meshHeading
pubmed:articleTitle
Downregulation of AP-1 repressor JDP2 is associated with tumor metastasis and poor prognosis in patients with pancreatic carcinoma.
pubmed:affiliation
Department of Pancreatic and Gastroenterologic Surgery, First Hospital of China Medical University, Shenyang, China. xu_yuanhong@yahoo.com
pubmed:publicationType
Journal Article