Linked Life Data

2066624

Source:http://linkedlifedata.com/resource/pubmed/id/2066624

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-8-15
pubmed:abstractText
The mechanism of bone remodeling has been investigated by many researchers. However, little is known about the role of the local factors which exist in the bone matrix. In this study, the author attempted to purify the bone-resorbing factor from the bovine bone matrix and to find its role in bone remodeling. The demineralized bovine bone matrix was extracted with 4M Gdn-HCl and the bone-resorbing factor was purified by means of heparin affinity and gel filtration chromatography. The analysis of bone resorption was carried out by the measurement of the released 45Ca from the pre-labeled mouse calvariae. The results of this study were that the bone-resorbing factor in the bone matrix was suggested to be a heat-stable glycoprotein having a molecular size higher than 150,000, which stimulated osteoclastic bone resorption via a prostaglandin-mediated mechanism.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0300-9149
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
155-68
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
[Partial purification and characterization of bone-resorbing factor from bovine bone matrix].
pubmed:affiliation
Second Department of Oral Surgery, Faculty of Dentistry, Tokyo Medical and Dental University.
pubmed:publicationType
Journal Article, English Abstract