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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0008633,
umls-concept:C0011860,
umls-concept:C0127400,
umls-concept:C0332120,
umls-concept:C0332307,
umls-concept:C0683983,
umls-concept:C0936012,
umls-concept:C1305855,
umls-concept:C1332838,
umls-concept:C1847163
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pubmed:issue |
4
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pubmed:dateCreated |
2010-9-20
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pubmed:abstractText |
Chromosome 20q12-q13.1 has been linked to type 2 diabetes (T2D) in multiple populations. We examined the influence of genes in this region on T2D and BMI in two European American case-control populations. SNPs were genotyped in 300 diabetic patients and 310 controls. A subset of 72 SNPs were further genotyped in 470 cases and 442 controls. All genes examined showed evidence of association with T2D in the initial sample (additive P-value [P(a)]=0.00090-0.045). SNPs near PREX1 were also associated in the second case-control population (P(a)=0.017-0.042). The combined analysis resulted in the same SNPs, among others, associated with T2D (P(a)=0.0013-0.041). Stratification analysis by T2D status showed that association with BMI was observed solely in cases (P(a)=0.0018-0.041). Mediation testing revealed that 30-40% of the effects of these SNPs on T2D were significantly mediated by BMI. SNPs near PREX1 may contribute to T2D susceptibility mediated through effects of adiposity in European Americans.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1089-8646
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pubmed:author |
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pubmed:copyrightInfo |
Published by Elsevier Inc.
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pubmed:issnType |
Electronic
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pubmed:volume |
96
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
211-9
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pubmed:dateRevised |
2011-10-3
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pubmed:meshHeading |
pubmed-meshheading:20650312-Adiposity,
pubmed-meshheading:20650312-Americas,
pubmed-meshheading:20650312-Body Mass Index,
pubmed-meshheading:20650312-Case-Control Studies,
pubmed-meshheading:20650312-Chromosomes, Human, Pair 20,
pubmed-meshheading:20650312-Diabetes Mellitus, Type 2,
pubmed-meshheading:20650312-European Continental Ancestry Group,
pubmed-meshheading:20650312-Gene Frequency,
pubmed-meshheading:20650312-Genetic Association Studies,
pubmed-meshheading:20650312-Genetic Predisposition to Disease,
pubmed-meshheading:20650312-Guanine Nucleotide Exchange Factors,
pubmed-meshheading:20650312-Humans,
pubmed-meshheading:20650312-Kidney Failure, Chronic,
pubmed-meshheading:20650312-Linkage Disequilibrium,
pubmed-meshheading:20650312-Middle Aged,
pubmed-meshheading:20650312-Polymorphism, Single Nucleotide
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pubmed:year |
2010
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pubmed:articleTitle |
Analysis of candidate genes on chromosome 20q12-13.1 reveals evidence for BMI mediated association of PREX1 with type 2 diabetes in European Americans.
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pubmed:affiliation |
Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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