Source:http://linkedlifedata.com/resource/pubmed/id/20646048
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2010-8-19
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| pubmed:abstractText |
Encoding of novel information has been proposed to rely on the time-locked release of dopamine in the hippocampal formation during novelty detection. However, the site of novelty detection in the hippocampus remains a matter of debate. According to current models, the CA1 and the subiculum act as detectors and distributors of novel sensory information. Although most CA1 pyramidal neurons exhibit regular-spiking behavior, the majority of subicular pyramidal neurons fire high-frequency bursts of action potentials. The present study investigates the efficacy of dopamine D1/D5 receptor activation to facilitate the induction of activity-dependent long-term potentiation (LTP) in rat CA1 regular-spiking and subicular burst-spiking pyramidal cells. Using a weak stimulation protocol, set at a level subthreshold for the induction of LTP, we show that activation of D1/D5 receptors for 5-10 min facilitates LTP in subicular burst-spiking neurons but not in CA1 neurons. The results demonstrate that D1/D5 receptor-facilitated LTP is NMDA receptor-dependent, and requires the activation of protein kinase A. In addition, the D1/D5 receptor-facilitated LTP is shown to be presynaptically expressed and relies on presynaptic Ca(2+) signaling. The phenomenon of dopamine-induced facilitation of presynaptic NMDA receptor-dependent LTP in subicular burst-spiking pyramidal cells is in accordance with observations of the time-locked release of dopamine during novelty detection in this brain region, and reveals an intriguing mechanism for the encoding of hippocampal output information.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,3,4,5-Tetrahydro-7,8-dihydroxy-1-p...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D5
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1460-9568
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
32
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
598-605
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| pubmed:meshHeading |
pubmed-meshheading:20646048-2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine,
pubmed-meshheading:20646048-Action Potentials,
pubmed-meshheading:20646048-Animals,
pubmed-meshheading:20646048-Calcium,
pubmed-meshheading:20646048-Cell Membrane,
pubmed-meshheading:20646048-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:20646048-Dopamine Agonists,
pubmed-meshheading:20646048-Enzyme Activation,
pubmed-meshheading:20646048-Female,
pubmed-meshheading:20646048-Hippocampus,
pubmed-meshheading:20646048-Humans,
pubmed-meshheading:20646048-Long-Term Potentiation,
pubmed-meshheading:20646048-Male,
pubmed-meshheading:20646048-Patch-Clamp Techniques,
pubmed-meshheading:20646048-Presynaptic Terminals,
pubmed-meshheading:20646048-Rats,
pubmed-meshheading:20646048-Rats, Wistar,
pubmed-meshheading:20646048-Receptors, Dopamine D1,
pubmed-meshheading:20646048-Receptors, Dopamine D5,
pubmed-meshheading:20646048-Synapses
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| pubmed:year |
2010
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| pubmed:articleTitle |
Activation of dopamine D1/D5 receptors facilitates the induction of presynaptic long-term potentiation at hippocampal output synapses.
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| pubmed:affiliation |
Department of Psychiatry and Psychotherapy, Charité- Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117 Berlin, Germany.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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