Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-7-20
pubmed:abstractText
Atrial fibrillation (AF) and obesity have reached epidemic proportions. The impact of obesity on clinical outcomes in patients with established AF is unknown. We analyzed 2,492 patients in the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) study. Body mass index (BMI) was evaluated as a categorical variable (normal 18.5 to <25 kg/m(2), overweight 25 to <30 kg/m(2), obese >or=30 kg/m(2)). Rate of death from any cause was higher in the normal BMI group (5.8 per 100 patient-years) than in the overweight and obese groups (3.9 and 3.7, respectively). Cardiovascular death rate was highest in the normal BMI group (3.1 per 100 patient-years), lowest in the overweight group (1.5 per 100 patient-years), and intermediate in the obese group (2.1 per 100 patient-years). After adjustment for baseline factors, differences in risk of death from any cause were no longer significant. However, overweight remained associated with a lower risk of cardiovascular death (hazard ratio 0.47, p = 0.002). Obese patients were more likely to have an uncontrolled heart rate at rest, but rhythm-control strategy success was similar across BMI categories. In each BMI category, risk of death from any cause was similar for patients randomized to a rhythm- or rate-control strategy. In conclusion, in patients with established AF, overweight and obesity do not adversely affect overall survival. Obesity does not appear to affect the relative benefit of a rate- or rhythm-control strategy.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-10511607, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-10600783, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-12466506, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-12672310, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-15093881, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-15562125, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-15642875, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-15652713, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-16920472, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-17040928, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-17174642, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-18215602, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-18270214, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-18285562, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-18363693, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-18585492, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-18611964, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-18641109, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-18654066, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-18786478, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-19005195, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-21757046, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-7637744, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-8594834, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-9107242, http://linkedlifedata.com/resource/pubmed/commentcorrection/20643247-9164885
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1879-1913
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
106
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
369-73
pubmed:dateRevised
2011-8-30
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Obesity and outcomes among patients with established atrial fibrillation.
pubmed:affiliation
George Washington University School of Public Health and Health Services, Washington, DC, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural