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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2010-9-29
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pubmed:abstractText |
Genome-wide association studies have identified a single nucleotide polymorphism (SNP), rs560887, located in a G6PC2 intron that is highly correlated with variations in fasting plasma glucose (FPG). G6PC2 encodes an islet-specific glucose-6-phosphatase catalytic subunit. This study examines the contribution of two G6PC2 promoter SNPs, rs13431652 and rs573225, to the association signal.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1939-327X
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pubmed:author |
pubmed-author:BaerenwaldDevin ADA,
pubmed-author:BalkauBeverleyB,
pubmed-author:BonnefondAmélieA,
pubmed-author:Bouatia-NajiNabilaN,
pubmed-author:BuglianiMarcoM,
pubmed-author:ConleyNicholas LNL,
pubmed-author:DinaChristianC,
pubmed-author:ElliottPaulP,
pubmed-author:FlemmingBrian PBP,
pubmed-author:FroguelPhilippeP,
pubmed-author:JarvelinMarjo-RiittaMR,
pubmed-author:Lévy-MarchalClaireC,
pubmed-author:LantieriOlivierO,
pubmed-author:MarchandMarionM,
pubmed-author:MarchettiPieroP,
pubmed-author:MarreMichelM,
pubmed-author:MeyreDavidD,
pubmed-author:O'BrienRichard MRM,
pubmed-author:OeserJames KJK,
pubmed-author:PattouFrançoisF,
pubmed-author:PrintzRichard LRL,
pubmed-author:UmunakweObi COC,
pubmed-author:VaxillaireMartineM
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pubmed:issnType |
Electronic
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2662-71
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pubmed:meshHeading |
pubmed-meshheading:20622168-Adult,
pubmed-meshheading:20622168-Blood Glucose,
pubmed-meshheading:20622168-Child,
pubmed-meshheading:20622168-Cohort Studies,
pubmed-meshheading:20622168-DNA Primers,
pubmed-meshheading:20622168-European Continental Ancestry Group,
pubmed-meshheading:20622168-Fasting,
pubmed-meshheading:20622168-Female,
pubmed-meshheading:20622168-Finland,
pubmed-meshheading:20622168-Gene Expression Regulation,
pubmed-meshheading:20622168-Genetic Variation,
pubmed-meshheading:20622168-Glucose-6-Phosphatase,
pubmed-meshheading:20622168-Humans,
pubmed-meshheading:20622168-Insulin Resistance,
pubmed-meshheading:20622168-Introns,
pubmed-meshheading:20622168-Metabolic Syndrome X,
pubmed-meshheading:20622168-Mothers,
pubmed-meshheading:20622168-Organ Specificity,
pubmed-meshheading:20622168-Polymorphism, Single Nucleotide,
pubmed-meshheading:20622168-Promoter Regions, Genetic,
pubmed-meshheading:20622168-RNA,
pubmed-meshheading:20622168-Reference Values
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pubmed:year |
2010
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pubmed:articleTitle |
Genetic and functional assessment of the role of the rs13431652-A and rs573225-A alleles in the G6PC2 promoter that are strongly associated with elevated fasting glucose levels.
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pubmed:affiliation |
CNRS-UMR-8199, Institut Pasteur de Lille, Lille, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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