| pubmed-article:20621718 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20621718 | lifeskim:mentions | umls-concept:C1556095 | lld:lifeskim |
| pubmed-article:20621718 | lifeskim:mentions | umls-concept:C0085508 | lld:lifeskim |
| pubmed-article:20621718 | lifeskim:mentions | umls-concept:C0302600 | lld:lifeskim |
| pubmed-article:20621718 | lifeskim:mentions | umls-concept:C1704242 | lld:lifeskim |
| pubmed-article:20621718 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:20621718 | lifeskim:mentions | umls-concept:C0596263 | lld:lifeskim |
| pubmed-article:20621718 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:20621718 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20621718 | pubmed:dateCreated | 2010-7-12 | lld:pubmed |
| pubmed-article:20621718 | pubmed:abstractText | Helicobacter pylori (H. pylori) is an important risk factor of gastric adenocarcinoma. Interleukin (IL)-8 is a potent angiogenic factor and plays an important role in inflammation of gastric mucosa by H. pylori. Host susceptibility may help to predict H. pylori-infected individuals with a higher risk of gastric adenocarcinoma. The aim of this study was to clarify the effect of IL-8 polymorphism on angiogenesis in the process of gastric carcinogenesis in H. pylori-infected Koreans. The IL-8-251A/T polymorphism was genotyped by PCR-RFLP from a total of 395 subjects; 92 normal controls, 87 H. pylori-infected controls, 108 chronic atrophic gastritis and/or intestinal metaplasia and 108 adenocarcinoma. The gastric mucosal concentrations of IL-8, membrane metalloproteinase (MMP)-9, angiopoietin (Ang)-1, and vascular endothelial growth factor (VEGF) were measured by ELISA. MMP-9 concentrations were increased with disease progression. There was significant correlation between MMP-9 and disease progression in AA (r=0.42, p<0.01) and AT genotype (r=0.43, p<0.01). Ang-1 concentrations were increased in AA genotype (r=0.40, p=0.01). However, there was no significant correlation between VEGF and disease progression in AA genotype. In conclusion, IL-8-251 AA genotype may be associated with angiogenesis in gastric carcinogenesis in H. pylori-infected Koreans. | lld:pubmed |
| pubmed-article:20621718 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20621718 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20621718 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20621718 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20621718 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20621718 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20621718 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20621718 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20621718 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20621718 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20621718 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20621718 | pubmed:issn | 1096-0023 | lld:pubmed |
| pubmed-article:20621718 | pubmed:author | pubmed-author:JungHyun... | lld:pubmed |
| pubmed-article:20621718 | pubmed:author | pubmed-author:SongIn SungIS | lld:pubmed |
| pubmed-article:20621718 | pubmed:author | pubmed-author:JungSung-AeSA | lld:pubmed |
| pubmed-article:20621718 | pubmed:author | pubmed-author:LeeMi... | lld:pubmed |
| pubmed-article:20621718 | pubmed:author | pubmed-author:SongJi HyunJH | lld:pubmed |
| pubmed-article:20621718 | pubmed:author | pubmed-author:KimSang... | lld:pubmed |
| pubmed-article:20621718 | pubmed:copyrightInfo | Copyright 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20621718 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20621718 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:20621718 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20621718 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20621718 | pubmed:pagination | 158-65 | lld:pubmed |
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| pubmed-article:20621718 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20621718 | pubmed:articleTitle | The interleukin-8-251 AA genotype is associated with angiogenesis in gastric carcinogenesis in Helicobacter pylori-infected Koreans. | lld:pubmed |
| pubmed-article:20621718 | pubmed:affiliation | Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Republic of Korea. | lld:pubmed |
| pubmed-article:20621718 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20621718 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:3576 | entrezgene:pubmed | pubmed-article:20621718 | lld:entrezgene |
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| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20621718 | lld:entrezgene |
