Source:http://linkedlifedata.com/resource/pubmed/id/20621718
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2010-7-12
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| pubmed:abstractText |
Helicobacter pylori (H. pylori) is an important risk factor of gastric adenocarcinoma. Interleukin (IL)-8 is a potent angiogenic factor and plays an important role in inflammation of gastric mucosa by H. pylori. Host susceptibility may help to predict H. pylori-infected individuals with a higher risk of gastric adenocarcinoma. The aim of this study was to clarify the effect of IL-8 polymorphism on angiogenesis in the process of gastric carcinogenesis in H. pylori-infected Koreans. The IL-8-251A/T polymorphism was genotyped by PCR-RFLP from a total of 395 subjects; 92 normal controls, 87 H. pylori-infected controls, 108 chronic atrophic gastritis and/or intestinal metaplasia and 108 adenocarcinoma. The gastric mucosal concentrations of IL-8, membrane metalloproteinase (MMP)-9, angiopoietin (Ang)-1, and vascular endothelial growth factor (VEGF) were measured by ELISA. MMP-9 concentrations were increased with disease progression. There was significant correlation between MMP-9 and disease progression in AA (r=0.42, p<0.01) and AT genotype (r=0.43, p<0.01). Ang-1 concentrations were increased in AA genotype (r=0.40, p=0.01). However, there was no significant correlation between VEGF and disease progression in AA genotype. In conclusion, IL-8-251 AA genotype may be associated with angiogenesis in gastric carcinogenesis in H. pylori-infected Koreans.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ANGPT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Angiopoietin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-8,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/VEGFA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A
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| pubmed:status |
MEDLINE
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| pubmed:month |
Aug
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| pubmed:issn |
1096-0023
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
51
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
158-65
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| pubmed:meshHeading |
pubmed-meshheading:20621718-Adenocarcinoma,
pubmed-meshheading:20621718-Adult,
pubmed-meshheading:20621718-Aged,
pubmed-meshheading:20621718-Angiopoietin-1,
pubmed-meshheading:20621718-Asian Continental Ancestry Group,
pubmed-meshheading:20621718-Disease Progression,
pubmed-meshheading:20621718-Female,
pubmed-meshheading:20621718-Gastric Mucosa,
pubmed-meshheading:20621718-Gastritis, Atrophic,
pubmed-meshheading:20621718-Genetic Predisposition to Disease,
pubmed-meshheading:20621718-Helicobacter Infections,
pubmed-meshheading:20621718-Helicobacter pylori,
pubmed-meshheading:20621718-Humans,
pubmed-meshheading:20621718-Interleukin-8,
pubmed-meshheading:20621718-Korea,
pubmed-meshheading:20621718-Male,
pubmed-meshheading:20621718-Matrix Metalloproteinase 9,
pubmed-meshheading:20621718-Metaplasia,
pubmed-meshheading:20621718-Middle Aged,
pubmed-meshheading:20621718-Neovascularization, Pathologic,
pubmed-meshheading:20621718-Polymorphism, Genetic,
pubmed-meshheading:20621718-Stomach Neoplasms,
pubmed-meshheading:20621718-Vascular Endothelial Growth Factor A
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| pubmed:year |
2010
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| pubmed:articleTitle |
The interleukin-8-251 AA genotype is associated with angiogenesis in gastric carcinogenesis in Helicobacter pylori-infected Koreans.
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| pubmed:affiliation |
Department of Internal Medicine, Healthcare Research Institute, Seoul National University Hospital Healthcare System Gangnam Center, Republic of Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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