Source:http://linkedlifedata.com/resource/pubmed/id/20620096
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2010-7-29
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| pubmed:abstractText |
We assessed the association of COX-2 polymorphisms at promoter sites -1195, -765 and at 3'UTR (8473) in 193 patients with oral squamous cell carcinoma (OSCC) and 137 normal subjects by PCR-RFLP. Although no significant difference was observed in the frequency of COX-2 -1195G>A, -765G>C and 8473C>T single nucleotide polymorphisms (SNPs) between patients and controls, COX-2 -1195G/A genotype showed higher while -765G/C and 8473C/T showed lower prevalence in patients as compared to normal subjects. Logistic regression analysis of these three polymorphisms revealed a quantitative risk associated with -1195G>A SNP (OR 3.07 at 95%CI) while -765G>C and 8473C>T appeared to be protective. Results of the present study indicate that these three functional variants in the COX-2 regulatory region may contribute to risk modification of tobacco-related oral squamous cell carcinoma in Asian Indians.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
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| pubmed:issn |
1368-8375
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright 2010 Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Print
|
| pubmed:volume |
46
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
622-6
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| pubmed:meshHeading |
pubmed-meshheading:20620096-Adult,
pubmed-meshheading:20620096-Aged,
pubmed-meshheading:20620096-Aged, 80 and over,
pubmed-meshheading:20620096-Asian Continental Ancestry Group,
pubmed-meshheading:20620096-Carcinoma, Squamous Cell,
pubmed-meshheading:20620096-Cyclooxygenase 2,
pubmed-meshheading:20620096-Female,
pubmed-meshheading:20620096-Genetic Predisposition to Disease,
pubmed-meshheading:20620096-Humans,
pubmed-meshheading:20620096-Male,
pubmed-meshheading:20620096-Middle Aged,
pubmed-meshheading:20620096-Mouth Neoplasms,
pubmed-meshheading:20620096-Neoplasm Proteins,
pubmed-meshheading:20620096-Polymorphism, Single Nucleotide,
pubmed-meshheading:20620096-Risk Factors,
pubmed-meshheading:20620096-Smoking,
pubmed-meshheading:20620096-Tobacco, Smokeless,
pubmed-meshheading:20620096-Young Adult
|
| pubmed:year |
2010
|
| pubmed:articleTitle |
Functional variants of COX-2 and risk of tobacco-related oral squamous cell carcinoma in high-risk Asian Indians.
|
| pubmed:affiliation |
Department of Biotechnology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India. manasimittal.1986@gmail.com
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|