Source:http://linkedlifedata.com/resource/pubmed/id/20598711
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2011-1-3
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| pubmed:abstractText |
The HOMER 1 protein plays a crucial role in mediating glutamatergic neurotransmission. It has previously shown to be a candidate gene for etiology and pathophysiology of different psychiatric diseases such as schizophrenia. To identify genes involved in response to antipsychotics, subgroups of animals were treated with haloperidol (1 mg/kg, n = 11) or saline (n = 12) for one week. By analyzing microarray data, we replicated the observed increase of Homer 1 gene expression. Furthermore, we genotyped 267 schizophrenic patients, who were treated monotherapeutically with different antipsychotics within randomized-controlled trials. Psychopathology was measured weekly using the PANSS for a minimum of four and a maximum of twelve weeks. Correlations between PANSS subscale scores at baseline and PANSS improvement scores after four weeks of treatment and genotypes were calculated by using a linear model for all investigated SNP's. We found an association between two HOMER 1 polymorphisms (rs2290639 and rs4704560) and different PANSS subscales at baseline. Furthermore all seven investigated polymorphisms were found to be associated with therapy response in terms of a significant correlation with different PANSS improvement subscores after four weeks of antipsychotic treatment. Most significant associations have been shown between the rs2290639 HOMER 1 polymorphism and PANSS subscales both at baseline conditions and after four weeks of antipsychotic treatment. This is the first study which shows an association between HOMER 1 polymorphisms and psychopathology data at baseline and therapy response in a clinical sample of schizophrenic patients. Thus, these data might further help in detecting differential therapy response in individuals with schizophrenia.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Feb
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| pubmed:issn |
1879-1379
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| pubmed:author |
pubmed-author:BondyBrigittaB,
pubmed-author:CeroveckiAnjaA,
pubmed-author:DehningSandraS,
pubmed-author:GeniusJustJ,
pubmed-author:GieglingInaI,
pubmed-author:HartmannAnnette MAM,
pubmed-author:MöllerHans-JürgenHJ,
pubmed-author:MüllerNorbertN,
pubmed-author:MayrAndreasA,
pubmed-author:MusilRichardR,
pubmed-author:Opgen-RheinMarkusM,
pubmed-author:RiedelMichaelM,
pubmed-author:RujescuDanD,
pubmed-author:SchäferMartinM,
pubmed-author:SpellmannIljaI,
pubmed-author:ZillPeterP
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| pubmed:copyrightInfo |
Copyright © 2010 Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
45
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
234-41
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| pubmed:meshHeading |
pubmed-meshheading:20598711-Adult,
pubmed-meshheading:20598711-Animals,
pubmed-meshheading:20598711-Antipsychotic Agents,
pubmed-meshheading:20598711-Carrier Proteins,
pubmed-meshheading:20598711-Female,
pubmed-meshheading:20598711-Gene Expression Regulation,
pubmed-meshheading:20598711-Gene Frequency,
pubmed-meshheading:20598711-Genome-Wide Association Study,
pubmed-meshheading:20598711-Genotype,
pubmed-meshheading:20598711-Haloperidol,
pubmed-meshheading:20598711-Humans,
pubmed-meshheading:20598711-Male,
pubmed-meshheading:20598711-Middle Aged,
pubmed-meshheading:20598711-Pharmacogenetics,
pubmed-meshheading:20598711-Polymorphism, Single Nucleotide,
pubmed-meshheading:20598711-Psychiatric Status Rating Scales,
pubmed-meshheading:20598711-Psychopathology,
pubmed-meshheading:20598711-Rats,
pubmed-meshheading:20598711-Rats, Long-Evans,
pubmed-meshheading:20598711-Schizophrenia,
pubmed-meshheading:20598711-Schizophrenic Psychology,
pubmed-meshheading:20598711-Young Adult
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| pubmed:year |
2011
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| pubmed:articleTitle |
Homer-1 polymorphisms are associated with psychopathology and response to treatment in schizophrenic patients.
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| pubmed:affiliation |
Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University of Munich, Nußbaumstrasse 7, 80336 Munich, Germany. ilja.spellmann@med.uni-muenchen.de
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| pubmed:publicationType |
Journal Article
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