Linked Life Data

20590148

Source:http://linkedlifedata.com/resource/pubmed/id/20590148

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-8-6
pubmed:abstractText
Three compounds were isolated from Acnistus arborescens, a tree commonly used in South and Central America in traditional medicine against several infectious diseases, some of which are caused by fungi. Bioassay-guided fractionation of a MeOH extract of leaves, based on its anti-Pneumocystis carinii activity, led to the isolation of compounds 1-3. Mono- and bidimensional NMR analyses enabled identification of two new withanolides, (20R,22R)-5beta,6beta-epoxy-4beta,12beta,20-trihydroxy-1-oxowith-2-en-24-enolide (1) and (20R,22R)-16beta-acetoxy-3beta,4beta;5beta,6beta-diepoxy-12beta,20-dihydroxy-1-oxowith-24-enolide (2), and withanolide D (3). Antifungal activity on 13 fungi responsible for human infections (five dermatophytes, one nondermatophyte mold, six yeasts, and Pneumocystis carinii) was examined. Cytotoxicity of these compounds was also evaluated in vitro.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1520-6025
pubmed:author
pubmed:issnType
Electronic
pubmed:day
23
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1313-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Antifungal and cytotoxic activity of withanolides from Acnistus arborescens.
pubmed:affiliation
Laboratoire de Pharmacognosie, EA4481 (GRIIOT), Faculte des Sciences Pharmaceutiques et Biologiques, Universite Lille Nord de France (Lille 2), Lille Cedex, France. vincent.roumy@univ-lille2.fr
pubmed:publicationType
Journal Article