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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
25
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pubmed:dateCreated |
2010-6-24
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pubmed:abstractText |
Ca(2+) influx through postsynaptic Ca(v)1.x L-type voltage-gated channels (LTCCs) is particularly effective in activating neuronal biochemical signaling pathways that might be involved in Hebbian synaptic plasticity (i.e., long-term potentiation and depression) and learning and memory. Here, we demonstrate that Ca(v)1.2 is the functionally relevant LTCC isoform in the thalamus-amygdala pathway of mice. We further show that acute pharmacological block of LTCCs abolishes Hebbian plasticity in the thalamus-amygdala pathway and impairs the acquisition of conditioned fear. On the other hand, chronic genetic loss of Ca(v)1.2 triggers a homeostatic change of the synapse, leading to a fundamental alteration of the mechanism of Hebbian plasticity by synaptic incorporation of Ca(2+)-permeable, GluA2-lacking AMPA receptors. Our results demonstrate for the first time the importance of the Ca(v)1.2 LTCC subtype in synaptic plasticity and fear memory acquisition.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1529-2401
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
23
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8367-75
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pubmed:meshHeading |
pubmed-meshheading:20573883-Amygdala,
pubmed-meshheading:20573883-Analysis of Variance,
pubmed-meshheading:20573883-Animals,
pubmed-meshheading:20573883-Blotting, Western,
pubmed-meshheading:20573883-Calcium Channels, L-Type,
pubmed-meshheading:20573883-Conditioning, Classical,
pubmed-meshheading:20573883-Electrophysiology,
pubmed-meshheading:20573883-Fear,
pubmed-meshheading:20573883-Homeostasis,
pubmed-meshheading:20573883-In Situ Hybridization,
pubmed-meshheading:20573883-Long-Term Potentiation,
pubmed-meshheading:20573883-Mice,
pubmed-meshheading:20573883-Mice, Transgenic,
pubmed-meshheading:20573883-Neural Pathways,
pubmed-meshheading:20573883-Neurons,
pubmed-meshheading:20573883-Receptors, AMPA,
pubmed-meshheading:20573883-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:20573883-Silver Staining,
pubmed-meshheading:20573883-Synapses,
pubmed-meshheading:20573883-Synaptic Transmission,
pubmed-meshheading:20573883-Thalamus,
pubmed-meshheading:20573883-Video Recording
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pubmed:year |
2010
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pubmed:articleTitle |
Homeostatic switch in hebbian plasticity and fear learning after sustained loss of Cav1.2 calcium channels.
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pubmed:affiliation |
Institute for Pharmacology, Technical University Munich, 80802 Munich, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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