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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-10-12
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pubmed:abstractText |
In view of the clinical similarities between polyarticular osteoarthritis (POA) with metacarpophalangeal (MCP) joint involvement and the arthropathy that occurs in hereditary haemochromatosis (HH), it was hypothesized that osteochondral damage in both disorders may be due to localized iron overload. Accordingly, it was predicted that the concentration of ferritin in synovial fluid (SF) would be higher in OA patients with HFE gene mutations than in HFE wild-type (wt) OA patients. The aim of this study was to test this proposition.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Ferritins,
http://linkedlifedata.com/resource/pubmed/chemical/HFE protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/LIF protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Leukemia Inhibitory Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinases,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tissue Inhibitor of...
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pubmed:status |
MEDLINE
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pubmed:issn |
1502-7732
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
39
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
413-20
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pubmed:meshHeading |
pubmed-meshheading:20560808-Adult,
pubmed-meshheading:20560808-Aged,
pubmed-meshheading:20560808-Aged, 80 and over,
pubmed-meshheading:20560808-Cytokines,
pubmed-meshheading:20560808-Female,
pubmed-meshheading:20560808-Ferritins,
pubmed-meshheading:20560808-Genotype,
pubmed-meshheading:20560808-Heterozygote,
pubmed-meshheading:20560808-Histocompatibility Antigens Class I,
pubmed-meshheading:20560808-Homozygote,
pubmed-meshheading:20560808-Humans,
pubmed-meshheading:20560808-Leukemia Inhibitory Factor,
pubmed-meshheading:20560808-Male,
pubmed-meshheading:20560808-Matrix Metalloproteinases,
pubmed-meshheading:20560808-Membrane Proteins,
pubmed-meshheading:20560808-Middle Aged,
pubmed-meshheading:20560808-Mutation,
pubmed-meshheading:20560808-Osteoarthritis, Knee,
pubmed-meshheading:20560808-Synovial Fluid,
pubmed-meshheading:20560808-Tissue Inhibitor of Metalloproteinase-1
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pubmed:year |
2010
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pubmed:articleTitle |
Ferritin concentrations in synovial fluid are higher in osteoarthritis patients with HFE gene mutations (C282Y or H63D).
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pubmed:affiliation |
University of Notre Dame and Department of Rheumatology, Fremantle Hospital, Australia. gjcarroll@optusnet.com.au
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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