Source:http://linkedlifedata.com/resource/pubmed/id/20541404
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
14
|
| pubmed:dateCreated |
2010-7-8
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| pubmed:abstractText |
A pyridazin-4-one fragment 4 (hCatS IC(50)=170 microM) discovered through Tethering was modeled into cathepsin S and predicted to overlap in S2 with the tetrahydropyridinepyrazole core of a previously disclosed series of CatS inhibitors. This fragment served as a template to design pyridazin-3-one 12 (hCatS IC(50)=430 nM), which also incorporates P3 and P5 binding elements. A crystal structure of 12 bound to Cys25Ser CatS led to the synthesis of the potent diazinone isomers 22 (hCatS IC(50)=60 nM) and 27 (hCatS IC(50)=40 nM).
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
1464-3405
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| pubmed:author |
pubmed-author:AmeriksMichael KMK,
pubmed-author:BembenekScott DSD,
pubmed-author:BurdettMatthew TMT,
pubmed-author:ChoongIngrid CIC,
pubmed-author:EdwardsJames PJP,
pubmed-author:GebauerDamaraD,
pubmed-author:GuYinY,
pubmed-author:KarlssonLarsL,
pubmed-author:PurkeyHans EHE,
pubmed-author:StakerBart LBL,
pubmed-author:SunSiquanS,
pubmed-author:ThurmondRobin LRL,
pubmed-author:ZhuJianJ
|
| pubmed:copyrightInfo |
2010 Elsevier Ltd. All rights reserved.
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| pubmed:issnType |
Electronic
|
| pubmed:day |
15
|
| pubmed:volume |
20
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
4060-4
|
| pubmed:meshHeading | |
| pubmed:year |
2010
|
| pubmed:articleTitle |
Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors.
|
| pubmed:affiliation |
Johnson & Johnson Pharmaceutical Research & Development, L.L.C., 3210 Merryfield Row, San Diego, CA 92121, USA. mameriks@its.jnj.com
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| pubmed:publicationType |
Journal Article
|