Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-7-12
pubmed:abstractText
Recently we have perfected a chemical-genetic approach to gain precise spatio-temporal control of cellular signaling. This approach entails the cell-type specific expression of mutant G-protein coupled receptors which have been evolved to be activated by the pharmacologically inert drug-like small molecule clozapine N-oxide. We have named these mutant GPCRs DREADDs (Designer Receptors Exclusively Activated by Designer Drugs). In this paper we will first review recent applications of this technology for the remote control of neuronal and non-neuronal signaling. Next, we will also introduce new variants which could be useful for the control of cellular signaling in discrete cellular compartments. Finally, we will suggest future basic science and therapeutic applications of this general technology.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/R01DA017204, http://linkedlifedata.com/resource/pubmed/grant/R01MH82447, http://linkedlifedata.com/resource/pubmed/grant/T32HD040127-07, http://linkedlifedata.com/resource/pubmed/grant/U19 MH082441-01, http://linkedlifedata.com/resource/pubmed/grant/U19 MH082441-010001, http://linkedlifedata.com/resource/pubmed/grant/U19 MH082441-019002, http://linkedlifedata.com/resource/pubmed/grant/U19 MH082441-019003, http://linkedlifedata.com/resource/pubmed/grant/U19 MH082441-02, http://linkedlifedata.com/resource/pubmed/grant/U19 MH082441-020001, http://linkedlifedata.com/resource/pubmed/grant/U19 MH082441-029002, http://linkedlifedata.com/resource/pubmed/grant/U19 MH082441-03, http://linkedlifedata.com/resource/pubmed/grant/U19 MH082441-030001, http://linkedlifedata.com/resource/pubmed/grant/U19 MH082441-03S1, http://linkedlifedata.com/resource/pubmed/grant/U19 MH082441-04, http://linkedlifedata.com/resource/pubmed/grant/U19 MH082441-040001, http://linkedlifedata.com/resource/pubmed/grant/U19 MH082441-05, http://linkedlifedata.com/resource/pubmed/grant/U19MH82441
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1742-2051
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1376-80
pubmed:dateRevised
2011-2-14
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
A chemical-genetic approach for precise spatio-temporal control of cellular signaling.
pubmed:affiliation
Departments of Pharmacology, University of North Carolina Medical School, 4009 Genetic Medicine Building, Chapel Hill, NC 27599-7365, USA.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural