Linked Life Data

20532262

Source:http://linkedlifedata.com/resource/pubmed/id/20532262

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SubjectPredicateObjectContext
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pubmed-article:20532262pubmed:dateCreated2010-7-15lld:pubmed
pubmed-article:20532262pubmed:abstractTextThe combination of the readily available chiral bisphosphine ligand Difluorphos with [Ir(COD)Cl](2) in THF resulted in a highly efficient catalyst system for asymmetric hydrogenation of quinolines at quite low catalyst loadings (0.05-0.002 mol%), affording the corresponding products with high enantioselectivities (up to 96%), excellent catalytic activities (TOF up to 3510 h(-1)) and productivities (TON up to 43000). The same catalyst was also successfully applied to the asymmetric hydrogenation of trisubstituted pyridines with nearly quantitative yields and up to 98% ee. In these two reactions, the addition of I(2) additive is indispensable; but the amount of I(2) has a different effect on catalytic performance.lld:pubmed
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pubmed-article:20532262pubmed:authorpubmed-author:ChanAlbert...lld:pubmed
pubmed-article:20532262pubmed:authorpubmed-author:WangTianliTlld:pubmed
pubmed-article:20532262pubmed:authorpubmed-author:TangWeijunWlld:pubmed
pubmed-article:20532262pubmed:authorpubmed-author:SunYaweiYlld:pubmed
pubmed-article:20532262pubmed:authorpubmed-author:LamKim-HungKHlld:pubmed
pubmed-article:20532262pubmed:authorpubmed-author:Lijin Xulld:pubmed
pubmed-article:20532262pubmed:authorpubmed-author:Qinghua Fanlld:pubmed
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pubmed-article:20532262pubmed:year2010lld:pubmed
pubmed-article:20532262pubmed:articleTitleHighly efficient and enantioselective hydrogenation of quinolines and pyridines with Ir-Difluorphos catalyst.lld:pubmed
pubmed-article:20532262pubmed:affiliationDepartment of Chemistry, Renmin University of China, Beijing 100872, China.lld:pubmed
pubmed-article:20532262pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20532262pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed