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20529685
Source:
http://linkedlifedata.com/resource/pubmed/id/20529685
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0178696
pubmed:issue
12
pubmed:dateCreated
2010-6-9
pubmed:abstractText
A series of N-aryl isonipecotamide alpha-sulfone hydroxamate derivatives has been prepared utilizing a combination of solution-phase and resin-bound library technologies to afford compounds that are potent and highly selective for MMP-13.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Amides
,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxamic Acids
,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 13
,
http://linkedlifedata.com/resource/pubmed/chemical/Small Molecule Libraries
,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfones
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1464-3405
pubmed:author
pubmed-author:BeckerDaniel PDP
,
pubmed-author:DeCrescenzoGary AGA
,
pubmed-author:FletcherTheresa RTR
,
pubmed-author:HockermanSusan LSL
,
pubmed-author:KolodziejStephen ASA
,
pubmed-author:McDonaldJoseph JJJ
,
pubmed-author:MischkeDebbie ADA
,
pubmed-author:MunieGrace EGE
,
pubmed-author:StehleNathanN
,
pubmed-author:SwearingenCraigC
pubmed:copyrightInfo
Copyright 2010 Elsevier Ltd. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3561-4
pubmed:meshHeading
pubmed-meshheading:20529685-Administration, Oral
,
pubmed-meshheading:20529685-Amides
,
pubmed-meshheading:20529685-Animals
,
pubmed-meshheading:20529685-Hydroxamic Acids
,
pubmed-meshheading:20529685-Inhibitory Concentration 50
,
pubmed-meshheading:20529685-Matrix Metalloproteinase 13
,
pubmed-meshheading:20529685-Rats
,
pubmed-meshheading:20529685-Small Molecule Libraries
,
pubmed-meshheading:20529685-Solubility
,
pubmed-meshheading:20529685-Substrate Specificity
,
pubmed-meshheading:20529685-Sulfones
pubmed:year
2010
pubmed:articleTitle
MMP-13 selective isonipecotamide alpha-sulfone hydroxamates.
pubmed:affiliation
Department of Medicinal Chemistry, Pfizer Research & Development, St. Louis, MO 63198, USA.
pubmed:publicationType
Journal Article