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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2010-5-31
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pubmed:abstractText |
The human Src homology 3 (SH3) domain GRB2-like 2 (SH3GL2) gene, a novel tumor suppressor gene in laryngeal squamous cell carcinoma (LSCC), induces apoptosis of tumor cells by regulating intra-cellular signal transduction networks. The objective of this study was to investigate the molecular mechanism of SH3GL2 in laryngeal carcinogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Epidermal Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/SH3GL2 protein, human
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1643-3750
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
BR168-73
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pubmed:meshHeading |
pubmed-meshheading:20512084-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:20512084-Apoptosis,
pubmed-meshheading:20512084-Cell Line, Tumor,
pubmed-meshheading:20512084-DNA Primers,
pubmed-meshheading:20512084-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20512084-Humans,
pubmed-meshheading:20512084-Laryngeal Neoplasms,
pubmed-meshheading:20512084-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:20512084-Mitogen-Activated Protein Kinase Kinases,
pubmed-meshheading:20512084-Models, Biological,
pubmed-meshheading:20512084-Phosphorylation,
pubmed-meshheading:20512084-RNA, Small Interfering,
pubmed-meshheading:20512084-Receptor, Epidermal Growth Factor,
pubmed-meshheading:20512084-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20512084-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
SH3GL2 gene participates in MEK-ERK signal pathway partly by regulating EGFR in the laryngeal carcinoma cell line Hep2.
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pubmed:affiliation |
Department of Neurobiology, China Medical University, Shenyang, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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