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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2010-8-12
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pubmed:abstractText |
Studies have shown that in systemic sclerosis (SSc) endothelial cells, overproduction of matrix metalloproteinase 12 (MMP-12) and pentraxin 3 (PTX3) is associated with defective angiogenesis. This study was undertaken to examine whether overexpression of the relevant molecules could inhibit angiogenesis of normal microvascular endothelial cells (MVECs), and whether silencing of these molecules in SSc MVECs could restore the lost angiogenic properties of the cells in vitro and in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1529-0131
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pubmed:author |
pubmed-author:AnastasiaChillàC,
pubmed-author:BazzichiLauraL,
pubmed-author:BianchiniFrancescaF,
pubmed-author:BombardieriStefanoS,
pubmed-author:CaloriniLidoL,
pubmed-author:Del RossoMarioM,
pubmed-author:KahalehBasharB,
pubmed-author:LapucciAndreaA,
pubmed-author:MORELLHH,
pubmed-author:MargheriFrancescaF,
pubmed-author:SerratìSimonaS
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pubmed:issnType |
Electronic
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2488-98
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pubmed:meshHeading |
pubmed-meshheading:20506099-Blotting, Western,
pubmed-meshheading:20506099-C-Reactive Protein,
pubmed-meshheading:20506099-Cell Movement,
pubmed-meshheading:20506099-Cell Proliferation,
pubmed-meshheading:20506099-Endothelial Cells,
pubmed-meshheading:20506099-Endothelium, Vascular,
pubmed-meshheading:20506099-Humans,
pubmed-meshheading:20506099-Matrix Metalloproteinase 12,
pubmed-meshheading:20506099-Neovascularization, Pathologic,
pubmed-meshheading:20506099-Neovascularization, Physiologic,
pubmed-meshheading:20506099-Scleroderma, Systemic,
pubmed-meshheading:20506099-Serum Amyloid P-Component,
pubmed-meshheading:20506099-Transfection
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pubmed:year |
2010
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pubmed:articleTitle |
Modulation of the angiogenic phenotype of normal and systemic sclerosis endothelial cells by gain-loss of function of pentraxin 3 and matrix metalloproteinase 12.
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pubmed:affiliation |
University of Florence, Florence, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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