Linked Life Data

20493955

Source:http://linkedlifedata.com/resource/pubmed/id/20493955

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-7-26
pubmed:abstractText
The memory-guided saccade paradigm is an ideal experimental model for studying spatial working memory. Both the posterior parietal cortex and frontal cortex are known to play a role in working memory; however, there is much debate about the degree of their involvement in the retention of information. We used event-related potentials and electromagnetic tomography to clarify the precise time course and location of the neural correlates of spatial working memory during a memory-guided saccade task in humans. We observed sustained activity in the inferior parietal lobe and extrastriate areas that persisted for the entire duration of the sensory- and memory-phases. This time course reveals that these regions participate in both initial sensory processing of visual cues and in the short-term maintenance of spatial location memory. Similar sustained activation was also observed in the anterior cingulate cortex, probably reflecting attentive control during the task. Differential activity between conditions was also recorded in the dorsolateral prefrontal cortex and in the frontal eye fields, but only during the initial part of the memory-phase. This finding suggests that these areas are not involved in the storage of spatial information, but rather in response selection and in transformation of spatial information into a motor coordinate framework, respectively. By exploiting techniques that provide exquisite temporal resolution and reasonably precise anatomical localization, this study provides evidence supporting the key role of inferior parietal lobe in the storage of spatial information during a working memory guided saccade.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1095-9572
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1611-20
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
The when and where of spatial storage in memory-guided saccades.
pubmed:affiliation
Cognitive Neuroscience Section, IRCCS San Giovanni di Dio Fatebenefratelli, Brescia, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't