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rdf:type |
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lifeskim:mentions |
umls-concept:C0011155,
umls-concept:C0024432,
umls-concept:C0032043,
umls-concept:C0032962,
umls-concept:C0041178,
umls-concept:C0085295,
umls-concept:C0086418,
umls-concept:C0086860,
umls-concept:C0443199,
umls-concept:C1705004,
umls-concept:C1879547
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|
pubmed:issue |
3
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|
pubmed:dateCreated |
2010-11-5
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pubmed:abstractText |
polymorphic changes in the IL-10 gene promoter have been identified that lead to altered IL-10 production. We hypothesized that because of these genotypic changes, the IL-10 promoter might be expressed in a cell type-specific manner and may respond differentially to inflammatory triggers.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
|
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pubmed:issn |
1600-0897
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
179-87
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pubmed:meshHeading |
pubmed-meshheading:20482524-Cell Line,
pubmed-meshheading:20482524-Cloning, Molecular,
pubmed-meshheading:20482524-Female,
pubmed-meshheading:20482524-Haplotypes,
pubmed-meshheading:20482524-Humans,
pubmed-meshheading:20482524-Interleukin-10,
pubmed-meshheading:20482524-Macrophages,
pubmed-meshheading:20482524-Organ Specificity,
pubmed-meshheading:20482524-Placenta Diseases,
pubmed-meshheading:20482524-Polymorphism, Genetic,
pubmed-meshheading:20482524-Pregnancy,
pubmed-meshheading:20482524-Pregnancy Complications,
pubmed-meshheading:20482524-Promoter Regions, Genetic,
pubmed-meshheading:20482524-Transcriptional Activation,
pubmed-meshheading:20482524-Trophoblasts
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|
pubmed:year |
2010
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pubmed:articleTitle |
Haplotype-dependent differential activation of the human IL-10 gene promoter in macrophages and trophoblasts: implications for placental IL-10 deficiency and pregnancy complications.
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pubmed:affiliation |
Department of Pediatrics, Women and Infants Hospital-Warren Alpert Medical School of Brown University, Providence, Rhode Island 02905, USA. ssharma@wihri.org
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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