Linked Life Data

20456322

Source:http://linkedlifedata.com/resource/pubmed/id/20456322

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-7-13
pubmed:abstractText
A review of the osteogenic cell activity and new bone growth in the regions bordering negatively charged surfaces of polarized Hydroxyapatite/beta-tricalcium phosphate (HA/TCP) composites implanted in the long bone in rabbits was conducted. Polarized and non-polarized HA/TCP specimens were implanted into the right and left femoral condyle, respectively (each n = 10). After 3 and 6 weeks, five rabbits were sacrificed in each group, and histological analysis was administered. Large cuboidal-shaped osteoblastic cells were predominantly observed lining the newly formed bone on the negatively charged surface (N-surface) in the polarized HA/TCP implants. The TRAP-positive multinucleated cells were observed extensively in the newly formed bone on the N-surfaces compared with the 0-surface and adhered directly to the HA/TCP composite. The bone area (B.Ar) value, newly formed bone area contacting the implant, and contact length (C.Le) value, percentage length of newly formed bone directly attaching to the implant, on both the 0- and N-surface increased significantly with time in each group. Both the B.Ar and C.Le value on the N-surface were significantly greater than those on the 0-surface after 3 and 6 weeks. The number of TRAP-positive cells/total length value on the N-surface was significantly greater than that on the 0-surface after 3 and 6 weeks postoperatively. It is hypothesized that electrical charge acquired by electrical polarization treatment may modify the biochemical and biophysical processes of the osteogenic cells, resulting in enhanced new bone formation and direct bonding between the recipient bone and implants.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1525-1594
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
491-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Enhanced bone bonding of the hydroxyapatite/beta-tricalcium phosphate composite by electrical polarization in rabbit long bone.
pubmed:affiliation
Department of Inorganic Materials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan.
pubmed:publicationType
Journal Article