Linked Life Data

20441162

Source:http://linkedlifedata.com/resource/pubmed/id/20441162

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-5-28
pubmed:abstractText
The action of maslinic acid (2alpha,3beta-dihydroxyolean-12-en-28-oic acid) (1), a pentacyclic derivative present in the pressed fruits of the olive (Olea europaea), has been studied against the tachyzoites of Toxoplasma gondii. The capability of tachyzoites to infect Vero cells treated with 1 was affected. The LD(50) values were 58.2 muM for the isolated tachyzoites and 236 muM for the noninfected Vero cells. Zymograms of the T. gondii proteases incubated with 1 showed a dosage-dependent inhibition of some of the proteases. The parasites treated with 1 showed gliding motility and ultrastructural alterations. The present findings suggest that protease activity of the parasite required for cell invasion is the action target for maslinic acid (1).
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1520-6025
pubmed:author
pubmed:issnType
Electronic
pubmed:day
28
pubmed:volume
73
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
831-4
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Action of a pentacyclic triterpenoid, maslinic acid, against Toxoplasma gondii.
pubmed:affiliation
Biochemical and Molecular Parasitology Group, Biotechnology Institute, Campus de Fuentenueva, University of Granada, 18071, Granada, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't