Linked Life Data

20432448

Source:http://linkedlifedata.com/resource/pubmed/id/20432448

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-5-31
pubmed:abstractText
Metastasizing prostate tumor cells invade along nerves innervating the encapsulated human prostate gland in a process known as perineural invasion. The extracellular matrix laminin class of proteins line the neural route and tumor cells escaping from the gland express the laminin binding integrin alpha6beta1 as a prominent cell surface receptor. Integrin alpha6beta1 promotes aggressive disease and supports prostate tumor cell metastasis to bone. Laminins and their integrin receptors are necessary for the development and maintenance of the peripheral nervous system, indicating the potential role for integrin receptors in directing prostate tumor cell invasion on nerves during perineural invasion.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1097-4652
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
224
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-8
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
The laminin binding integrin alpha6beta1 in prostate cancer perineural invasion.
pubmed:affiliation
Department of Pharmacology, The University of Arizona, Tucson, Arizona, USA.
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural