Linked Life Data

20425164

Source:http://linkedlifedata.com/resource/pubmed/id/20425164

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-4-28
pubmed:abstractText
A substantial proportion of patients with severe aortic stenosis may paradoxically have low transvalvular flow and a low gradient, despite the presence of normal left ventricular (LV) ejection fraction. These patients are characterized by pronounced LV concentric remodeling with small LV cavity size, impaired LV filling, altered myocardial function, and worse prognosis. This frequent clinical entity is often misdiagnosed, which may lead to an underestimation of aortic stenosis severity and thereby to underutilization or inappropriate delay of surgery. It is important to recognize this entity so we do not deny surgery to a symptomatic patient with small aortic valve area and low gradient. Thus, when there is a discordance between the valve area (in the severe range) and the gradient (in the moderate range) in patients with preserved LV ejection fraction, a more comprehensive Doppler echocardiographic evaluation and potentially other diagnostic tests may be required to confirm disease severity and guide therapeutic management.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1534-3170
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
108-15
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Low-flow, low-gradient, normal ejection fraction aortic stenosis.
pubmed:affiliation
Institut Universitaire de Cardiologie et de Pneumologie de Québec, Canada. philippe.pibarot@med.ulaval.ca
pubmed:publicationType
Journal Article, Review, Case Reports, Research Support, Non-U.S. Gov't